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C57BL/6JCya-Srbd1em1flox/Cya
Common Name:
Srbd1-flox
Product ID:
S-CKO-17715
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Price:
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Basic Information
Strain Name
Srbd1-flox
Strain ID
CKOCMP-78586-Srbd1-B6J-VB
Gene Name
Srbd1
Product ID
S-CKO-17715
Gene Alias
D530025C17Rik
Background
C57BL/6JCya
NCBI ID
78586
Modification
Conditional knockout
Chromosome
17
Phenotype
MGI:1925836
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Srbd1em1flox/Cya mice (Catalog S-CKO-17715) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000095187
NCBI RefSeq
NM_030133
Target Region
Exon 3~4
Size of Effective Region
~3.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Srbd1, the S1 RNA-binding domain-containing protein 1, is an essential gene with diverse functions. It is involved in chromosome segregation, safeguarding the genome during mitosis. It also participates in regulating the cell cycle, apoptosis, and macrophage polarization, with implications in cancer-related pathways such as the RPL11-MDM2-p53 pathway [3]. Additionally, Srbd1 has been associated with glaucoma, suggesting its role in eye-related pathologies [5,6,7]. Genetic models, like those in dogs, can be valuable for studying its function [7].

In functional studies, inactivation of Srbd1 in cells causes micronuclei, chromatin bridges, and cell death. Specifically, inactivating Srbd1 prior to mitotic entry leads to anaphase failure, with reduced topoisomerase IIα localization to mitotic chromosomes and defects in chromosome condensation and decatenation [1]. The loss of Srbd1 results in a pronounced defect in sister chromatid segregation, resembling the phenotype of topoisomerase IIα (TOP2A) dysfunction [2]. In glioma, upregulation of Srbd1 activates the p53 signaling pathway through promoting RPL11 binding to MDM2, suppressing glioma growth [3]. In nucleus pulposus cells, knockdown of the selective autophagy receptor NBR1 leads to the accumulation of Srbd1, which triggers cellular senescence via AKT1/p53 and RB/p16 pathways, and promotes the senescence-associated secretory phenotype (SASP) via the NF-κβ pathway [4].

In summary, Srbd1 is crucial for chromosome organization and segregation during mitosis. Its role in the RPL11-MDM2-p53 pathway in glioma and its association with cellular senescence in nucleus pulposus cells highlight its significance in cancer and age-related degenerative diseases. The study of Srbd1 using gene-knockout models in various organisms provides insights into its functions and potential therapeutic targets for related diseases.

References:
1. Lovejoy, Courtney A, Wessel, Sarah R, Bhowmick, Rahul, Zhao, Runxiang, Cortez, David. 2025. SRBD1 facilitates chromosome segregation by promoting topoisomerase IIα localization to mitotic chromosomes. In Nature communications, 16, 1675. doi:10.1038/s41467-025-56911-w. https://pubmed.ncbi.nlm.nih.gov/39955279/
2. Raaijmakers, Jonne A, Janssen, Louise M E, Mazouzi, Abdelghani, Brummelkamp, Thijn R, Medema, René H. 2025. SRBD1, a highly conserved gene required for chromosome individualization. In Cell reports, 44, 115443. doi:10.1016/j.celrep.2025.115443. https://pubmed.ncbi.nlm.nih.gov/40106440/
3. Chen, Hongfu, Gao, Shuping, Wang, Peng, Nie, Er, Lan, Qing. 2024. SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11-MDM2-p53 Pathway in Glioma. In Environmental toxicology, 40, 66-78. doi:10.1002/tox.24396. https://pubmed.ncbi.nlm.nih.gov/39258423/
4. Song, Honghai, Zhu, Yutao, Hu, Chuan, Liu, Zhili, Hu, Zhijun. 2024. Selective Autophagy Receptor NBR1 Retards Nucleus Pulposus Cell Senescence by Directing the Clearance of SRBD1. In International journal of biological sciences, 20, 701-717. doi:10.7150/ijbs.90186. https://pubmed.ncbi.nlm.nih.gov/38169523/
5. Pan, Lijie, Wu, Jian, Wang, Ningli. 2024. Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis. In Genes, 15, . doi:10.3390/genes15040491. https://pubmed.ncbi.nlm.nih.gov/38674425/
6. Graham, K L, McCowan, C, White, A. 2016. Genetic and Biochemical Biomarkers in Canine Glaucoma. In Veterinary pathology, 54, 194-203. doi:10.1177/0300985816666611. https://pubmed.ncbi.nlm.nih.gov/27681326/
7. Kanemaki, Nobuyuki, Tchedre, Kissaou T, Imayasu, Masaki, Meguro, Akira, Mizuki, Nobuhisa. 2013. Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk. In PloS one, 8, e74372. doi:10.1371/journal.pone.0074372. https://pubmed.ncbi.nlm.nih.gov/24040232/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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