C57BL/6JCya-Syncripem1flox/Cya
Common Name:
Syncrip-flox
Product ID:
S-CKO-17718
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Syncrip-flox
Strain ID
CKOCMP-56403-Syncrip-B6J-VC
Gene Name
Product ID
S-CKO-17718
Gene Alias
2610109K23Rik; 4632417O19Rik; GRY-RBP; Nsap1; Nsap1l; hnRNP Q; pp68
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Syncripem1flox/Cya mice (Catalog S-CKO-17718) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000069221
NCBI RefSeq
NM_019796
Target Region
Exon 3~4
Size of Effective Region
~0.8 kb
Detailed Document
Overview of Gene Research
SYNCRIP, also known as hnRNP Q, is an RNA-binding protein belonging to the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. It is involved in multiple biological processes such as post-transcriptional regulation, miRNA biogenesis, and proteostasis maintenance. It participates in pathways related to cell development, homeostasis, and cancer-related processes, making it of great biological importance. Genetic models, like knockout mouse models, are valuable tools for studying its functions [2,3,4].
Using a conditional knockout mouse model, it was revealed that SYNCRIP is required for maintaining blood homeostasis, especially after regenerative stress. Loss of SYNCRIP led to a failure in proteome homeostasis in hematopoietic stem cells (HSCs), increased protein synthesis, and endoplasmic reticulum stress [2]. In prostate cancer cells, loss of SYNCRIP unleashed APOBEC-driven mutagenesis, which contributed to tumor heterogeneity and resistance to androgen receptor (AR)-targeted therapy. APOBEC3B, overactivated in SYNCRIP-deficient cells, was identified as a key mutator causing driver mutations in genes like FOXA1 and EP300 [1].
In conclusion, SYNCRIP plays essential roles in maintaining blood homeostasis and in cancer-related processes. The use of KO/CKO mouse models has been crucial in revealing its role in these areas, providing insights into how SYNCRIP-related dysfunctions can lead to diseases such as hematopoietic disorders and prostate cancer, and potentially guiding future therapeutic strategies.
References:
1. Li, Xiaoling, Wang, Yunguan, Deng, Su, Wang, Tao, Mu, Ping. 2023. Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer. In Cancer cell, 41, 1427-1449.e12. doi:10.1016/j.ccell.2023.06.010. https://pubmed.ncbi.nlm.nih.gov/37478850/
2. Herrejon Chavez, Florisela, Luo, Hanzhi, Cifani, Paolo, Vu, Ly P, Kharas, Michael G. 2023. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. In Nature communications, 14, 2290. doi:10.1038/s41467-023-38001-x. https://pubmed.ncbi.nlm.nih.gov/37085479/
3. Chen, Ying, Chan, Jingru, Chen, Wei, Yuan, Yuren Adam, Jobichen, Chacko. 2020. SYNCRIP, a new player in pri-let-7a processing. In RNA (New York, N.Y.), 26, 290-305. doi:10.1261/rna.072959.119. https://pubmed.ncbi.nlm.nih.gov/31907208/
4. Khudayberdiev, Sharof, Soutschek, Michael, Ammann, Irina, Baumeister, Stefan, Schratt, Gerhard. 2020. The cytoplasmic SYNCRIP mRNA interactome of mammalian neurons. In RNA biology, 18, 1252-1264. doi:10.1080/15476286.2020.1830553. https://pubmed.ncbi.nlm.nih.gov/33030396/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen