C57BL/6JCya-Gdaem1flox/Cya
Common Name:
Gda-flox
Product ID:
S-CKO-17793
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Gda-flox
Strain ID
CKOCMP-14544-Gda-B6J-VB
Gene Name
Product ID
S-CKO-17793
Gene Alias
GAH
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
19
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gdaem1flox/Cya mice (Catalog S-CKO-17793) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000087600
NCBI RefSeq
NM_010266.2
Target Region
Exon 3
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
Gda can refer to different entities. In the context of genes, lncRNA GDA-1 (also named Gda) is a long non-coding RNA. It promotes keratinocyte proliferation and psoriasis inflammation by regulating the STAT3/NF-κB signaling pathway via Forkhead Box M1 [1].
In the study, by silencing and overexpressing GDA-1 in NHEKs and Ker-CT cells, it was found that GDA-1 regulated cell proliferation and cell cycle, and increased the secretion of interleukin-1β (IL-1β), IL-6, and chemokine ligands 2 and 20 (CCL2 and CCL20). RNA sequencing after GDA-1 silencing identified a close regulatory relationship between GDA-1 and FOXM1. GDA-1 significantly influenced FOXM1 expression at both mRNA and protein levels and activated STAT3/NF-κB signaling pathways [1].
In conclusion, Gda in the form of lncRNA GDA-1 plays a crucial role in the pathogenesis of psoriasis by mediating the proliferation and inflammation of psoriatic keratinocytes through the STAT3/NF-κB signaling pathway. This finding may provide a potential target for psoriasis treatment [1].
References：
1. Li, Xueqing, Chen, Fuqiang, Ju, Jiaoying, Li, Zhengjun, Sun, Qing. 2023. Long Non-Coding RNA-GDA-1 Promotes Keratinocyte Proliferation and Psoriasis Inflammation by Regulating the STAT3/NF-κB Signaling Pathway via Forkhead Box M1. In Inflammation, 46, 1209-1220. doi:10.1007/s10753-023-01800-x. https://pubmed.ncbi.nlm.nih.gov/36943641/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen