C57BL/6JCya-D16Ertd472eem1flox/Cya
Common Name:
D16Ertd472e-flox
Product ID:
S-CKO-17878
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
D16Ertd472e-flox
Strain ID
CKOCMP-67102-D16Ertd472e-B6J-VB
Gene Name
Product ID
S-CKO-17878
Gene Alias
1700010I10Rik; 2310009O17Rik; E330003K22Rik; Eurl
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
16
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-D16Ertd472eem1flox/Cya mice (Catalog S-CKO-17878) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000232052
NCBI RefSeq
NM_001252438
Target Region
Exon 3~5
Size of Effective Region
~3.4 kb
Detailed Document
Overview of Gene Research
D16Ertd472e is a gene whose function, aliases, and associated pathways are not explicitly detailed in the provided abstract. However, its importance lies in the context of hepatic ischemia reperfusion (IR) injury research. It is among the genes whose alternative splicing was studied, indicating its potential role in processes related to transcript and protein diversity [1].
In a mouse model of hepatic IR injury, D16Ertd472e was one of 898 differentially alternatively spliced (DAS) genes (p ≤ 0.05) identified in the hepatic IR group compared to the sham group. The expression level of D16Ertd472e was verified by RT-PCR and qRT-PCR, suggesting its significance in the context of hepatic IR injury [1].
In conclusion, while the exact biological function of D16Ertd472e remains to be fully elucidated, its differential alternative splicing and expression verification in the hepatic IR injury mouse model indicate its potential importance in understanding the molecular mechanisms of this disease condition. The study of D16Ertd472e in this context contributes to a better understanding of hepatic IR injury and the underlying alternative pre-mRNA splicing dynamics [1].
References:
1. Hua, Yongliang, Li, Xinglong, Yin, Bing, Meng, Zhanzhi, Ma, Yong. 2024. Genome-wide analysis of alternative splicing differences in hepatic ischemia reperfusion injury. In Scientific reports, 14, 31349. doi:10.1038/s41598-024-82846-1. https://pubmed.ncbi.nlm.nih.gov/39732885/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen