C57BL/6JCya-Jmjd1cem1flox/Cya
Common Name:
Jmjd1c-flox
Product ID:
S-CKO-17882
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Jmjd1c-flox
Strain ID
CKOCMP-108829-Jmjd1c-B6J-VB
Gene Name
Product ID
S-CKO-17882
Gene Alias
5430433L24Rik; D630035I23Rik; Jmjdic; TRIP8
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Jmjd1cem1flox/Cya mice (Catalog S-CKO-17882) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000051446
NCBI RefSeq
NM_207221
Target Region
Exon 9~10
Size of Effective Region
~4.1 kb
Detailed Document
Overview of Gene Research
Jmjd1c, a member of JmjC domain histone demethylase, is involved in multiple biological processes. It participates in pathways related to cell differentiation, metabolism, and immune regulation, which are crucial for maintaining normal physiological functions and are associated with various diseases [1,2,3,4,5,6]. Genetic models, especially gene knockout (KO) and conditional knockout (CKO) mouse models, have been instrumental in studying its functions.
In B cells, Jmjd1c deficiency promotes plasma cell differentiation, leading to enhanced disease severity in rheumatoid arthritis (RA) as it causes STAT3 Lys140 hypermethylation, disrupting its interaction with Ptpn6 and sustaining abnormal phosphorylation and activity [1]. In tumor Treg cells, JMJD1C deletion enhances AKT and STAT3 signals, leading to interferon-γ production and Treg cell fragility, suggesting its role in tumor immune evasion [2]. In pulmonary arterial hypertension, JMJD1C knockdown suppresses hypoxia-induced pulmonary arterial smooth muscle cell (PASMC) hyperproliferation and glycolysis by inhibiting STAT3 activation [3].
In conclusion, Jmjd1c is a key regulator in multiple biological processes. Its KO/CKO mouse models have revealed its significance in diseases such as RA, cancer, and pulmonary arterial hypertension, contributing to our understanding of disease mechanisms and potential therapeutic targets.
References:
1. Yin, Yuye, Yang, Xinyi, Wu, Shusheng, Chen, Jingjing, Wang, Xiaoming. 2022. Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis. In Nature immunology, 23, 1342-1354. doi:10.1038/s41590-022-01287-y. https://pubmed.ncbi.nlm.nih.gov/35995859/
2. Long, Xuehui, Zhang, Sulin, Wang, Yuliang, Qin, Jun, Wang, Xiaoming. 2024. Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity. In Nature immunology, 25, 525-536. doi:10.1038/s41590-024-01746-8. https://pubmed.ncbi.nlm.nih.gov/38356061/
3. Zhang, Chen, Sun, Yue, Guo, Yingying, Xu, Jingjing, Zhao, Haiyan. 2023. JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension. In Cell death discovery, 9, 98. doi:10.1038/s41420-023-01390-5. https://pubmed.ncbi.nlm.nih.gov/36934091/
4. Chen, Qian, Wang, Saisai, Zhang, Juqing, Roeder, Robert G, Chen, Mo. 2024. JMJD1C forms condensates to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells. In Protein & cell, , . doi:10.1093/procel/pwae059. https://pubmed.ncbi.nlm.nih.gov/39450904/
5. Qi, Daoxin, Wang, Jialing, Zhao, Yao, Xu, Xin, Hu, Zhenbo. 2022. JMJD1C-regulated lipid synthesis contributes to the maintenance of MLL-rearranged acute myeloid leukemia. In Leukemia & lymphoma, 63, 2149-2160. doi:10.1080/10428194.2022.2068004. https://pubmed.ncbi.nlm.nih.gov/35468015/
6. Lynch, Jennifer R, Salik, Basit, Connerty, Patrick, Wang, Jianlong, Wang, Jenny Y. 2019. JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis. In Leukemia, 33, 1400-1410. doi:10.1038/s41375-018-0354-z. https://pubmed.ncbi.nlm.nih.gov/30622285/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen