C57BL/6JCya-Casp7em1flox/Cya
Common Name:
Casp7-flox
Product ID:
S-CKO-17912
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Casp7-flox
Strain ID
CKOCMP-12369-Casp7-B6J-VB
Gene Name
Product ID
S-CKO-17912
Gene Alias
CMH-1; ICE-IAP3; Mch3; caspase-7; mCASP-7
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
19
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Casp7em1flox/Cya mice (Catalog S-CKO-17912) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000026062
NCBI RefSeq
NM_007611.2
Target Region
Exon 3
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Casp7, a cysteine protease, is a member of the caspase family. It plays a crucial role in apoptosis, a genetically programmed cell death process vital for cellular homeostasis. Casp7 is involved in pathways related to innate immunity regulation, as well as the development and response to various diseases. Genetic models are valuable for studying its function and the impact of its genetic variations [3].
Casp7 has been associated with multiple disease conditions. In ischaemic stroke, the rs12415607 A allele in the promoter of Casp7 reduces the risk of the disease by inducing lower transcriptional activity and Casp7 mRNA levels [1]. In non-small cell lung cancer patients treated with platinum-based chemotherapy, certain Casp7 polymorphisms (rs2227310, rs4353229, rs12415607) are associated with better overall survival [2]. Additionally, in colorectal cancer, the rs2227310 GG genotype of Casp7 is correlated with worse disease-free and disease-specific survival [5]. It's also associated with childhood leukemia risk through its genetic polymorphisms [4].
In conclusion, Casp7 is essential in apoptosis and has a significant impact on various diseases, including ischaemic stroke, non-small cell lung cancer, colorectal cancer, and childhood leukemia. Genetic models, especially those related to Casp7 gene polymorphisms, have provided insights into its role in these disease conditions, contributing to our understanding of disease mechanisms and potential prognostic markers.
References:
1. Zheng, Zhaoshi, Liu, Songyan, Wang, Chuheng, Shi, Yuqing, Han, Xuemei. 2019. Association of genetic polymorphisms in CASP7 with risk of ischaemic stroke. In Scientific reports, 9, 18627. doi:10.1038/s41598-019-55201-y. https://pubmed.ncbi.nlm.nih.gov/31819117/
2. Qian, Ji, Gu, Shaohua, Wu, Qihan, Wei, Qingyi, Jin, Li. . Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment. In Chest, 142, 680-689. doi:10.1378/chest.11-2522. https://pubmed.ncbi.nlm.nih.gov/22441531/
3. Juan, T S, McNiece, I K, Argento, J M, Copeland, N G, Fletcher, F A. . Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3. In Genomics, 40, 86-93. doi:. https://pubmed.ncbi.nlm.nih.gov/9070923/
4. Park, Chulbum, Han, Sohee, Lee, Kyoung-Mu, Choi, Ji Eun, Kang, Daehee. 2012. Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia. In Human immunology, 73, 736-9. doi:10.1016/j.humimm.2012.04.017. https://pubmed.ncbi.nlm.nih.gov/22548721/
5. Chae, Yee Soo, Kim, Jong Gwang, Sohn, Sang Kyun, Choi, Gyu Seog, Jun, Soo-Han. 2010. RIPK1 and CASP7 polymorphism as prognostic markers for survival in patients with colorectal cancer after complete resection. In Journal of cancer research and clinical oncology, 137, 705-13. doi:10.1007/s00432-010-0929-1. https://pubmed.ncbi.nlm.nih.gov/20567846/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen