C57BL/6JCya-Coprsem1flox/Cya
Common Name:
Coprs-flox
Product ID:
S-CKO-17928
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Coprs-flox
Strain ID
CKOCMP-66423-Coprs-B6J-VB
Gene Name
Product ID
S-CKO-17928
Gene Alias
1700029I03Rik; 2410022L05Rik; Copr5
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Coprsem1flox/Cya mice (Catalog S-CKO-17928) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000033839
NCBI RefSeq
NM_025556.3
Target Region
Exon 2~3
Size of Effective Region
~2.6 kb
Detailed Document
Overview of Gene Research
Coprs, encoding a histone-binding protein, is highly expressed in the testis. It is essential for the targeting of Prmt5 activity, and Prmt5 is involved in retrotransposon repression through the piRNA pathway, which is crucial for genome integrity during germ cell development [1].
Genetic inactivation of Coprs in mice impacts the maturation of spermatogonia to spermatids. In coprs-/-mice, there is deregulation of Miwi and pachytene pre-piRNAs levels, along with derepression of LINE1 repetitive sequences. These findings from the KO mouse model suggest that Coprs is implicated in genome surveillance mechanisms in spermatocytes [1].
In conclusion, Coprs plays a vital role in the process of spermatogenesis and genome surveillance in the testis, as revealed by the Coprs KO mouse model. Understanding Coprs function contributes to our knowledge of germ cell development and the potential mechanisms underlying related disorders.
References：
1. Paul, Conception, Delpech, Hélène, Haouzi, Delphine, Sardet, Claude, Fabbrizio, Eric. 2018. Coprs inactivation leads to a derepression of LINE1 transposons in spermatocytes. In FEBS open bio, 9, 159-168. doi:10.1002/2211-5463.12562. https://pubmed.ncbi.nlm.nih.gov/30652083/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen