C57BL/6JCya-Gfyem1flox/Cya
Common Name:
Gfy-flox
Product ID:
S-CKO-17936
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Gfy-flox
Strain ID
CKOCMP-100039953-Gfy-B6J-VB
Gene Name
Product ID
S-CKO-17936
Gene Alias
Gm2515; Gm581; Goofy
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gfyem1flox/Cya mice (Catalog S-CKO-17936) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000179443
NCBI RefSeq
NM_001195255
Target Region
Exon 2~5
Size of Effective Region
~2.8 kb
Detailed Document
Overview of Gene Research
Gfy, a gene that has been associated with various biological aspects.
In deer mice, it is among candidate genes related to olfaction, potentially playing a role in predator-recognition traits at the molecular level [2].
In the green microalga Chlamydomonas reinhardtii, genes of five proteins belonging to the GPR1/FUN34/YaaH (GFY) superfamily were observed to have increased expression upon acetate addition, suggesting a possible role as intracellular membrane acetate channels [3].
Also, in a study on early-onset coronary artery disease in a Japanese population, Gfy was among 21 newly identified genes significantly associated with the disease [1].
No knockout (KO) or conditional knockout (CKO) mouse model-related information was found in the provided references.
In conclusion, Gfy seems to be involved in diverse biological functions such as olfaction in animals, acetate-related metabolism in microalgae, and potentially in the susceptibility to early-onset coronary artery disease. Although no KO/CKO mouse model data is available from these references, understanding Gfy's functions could provide insights into related biological processes and disease mechanisms.
References：
1. Yamada, Yoshiji, Yasukochi, Yoshiki, Kato, Kimihiko, Takeuchi, Ichiro, Sakuma, Jun. 2018. Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population. In Biomedical reports, 9, 383-404. doi:10.3892/br.2018.1152. https://pubmed.ncbi.nlm.nih.gov/30402224/
2. Orrock, John L, Abueg, Linelle, Gammie, Stephen, Munshi-South, Jason. 2021. Exome sequencing of deer mice on two California Channel Islands identifies potential adaptation to strongly contrasting ecological conditions. In Ecology and evolution, 11, 17191-17201. doi:10.1002/ece3.8357. https://pubmed.ncbi.nlm.nih.gov/34938502/
3. Durante, Lorenzo, Hübner, Wolfgang, Lauersen, Kyle J, Remacle, Claire. 2019. Characterization of the GPR1/FUN34/YaaH protein family in the green microalga Chlamydomonas suggests their role as intracellular membrane acetate channels. In Plant direct, 3, e00148. doi:10.1002/pld3.148. https://pubmed.ncbi.nlm.nih.gov/31245784/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen