C57BL/6JCya-Slc6a11em1flox/Cya
Common Name:
Slc6a11-flox
Product ID:
S-CKO-17988
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slc6a11-flox
Strain ID
CKOCMP-243616-Slc6a11-B6J-VB
Gene Name
Product ID
S-CKO-17988
Gene Alias
D930045G19Rik; E130202I16Rik; GAT4; Gabt4; Gat3
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc6a11em1flox/Cya mice (Catalog S-CKO-17988) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000032451
NCBI RefSeq
NM_172890
Target Region
Exon 4
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Slc6a11, also known as GAT3, is a gene encoding a sodium-and chloride-dependent GABA transporter. It belongs to the solute carrier 6 (SLC6) family of sodium-dependent transporters. GABA transporters play a crucial role in maintaining the homeostasis of γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system (CNS). By regulating extracellular GABA levels, Slc6a11 is involved in various neural functions and associated pathways, which are of great biological importance [4,6].
Regarding its role in diseases, a meta-analysis showed that the SLC6A11 rs2304725 polymorphism was not significantly correlated with drug-resistant epilepsy (DRE) in most models, except for the over-dominant model in a pooled population. Another study found no association between 14 SLC6A11 tagSNPs and DRE in the Chinese Han population. However, in a Korean sample, the SLC6A11 rs4684742 polymorphism was associated with tardive dyskinesia, and gene-gene interactions involving SLC6A11 were found to be related to the development of tardive dyskinesia. Also, whole-genome sequencing analysis identified SLC6A11 as a gene nominally associated with clozapine-induced myocarditis [1,2,3,5].
In conclusion, Slc6a11 is essential for GABA homeostasis in the CNS. Studies on its genetic polymorphisms have provided insights into its potential roles in diseases such as drug-resistant epilepsy, tardive dyskinesia, and clozapine-induced myocarditis. Although more research is needed, understanding Slc6a11's functions and associations with diseases may offer new perspectives for disease diagnosis and treatment.
References:
1. Hu, Xuemei, Zhao, Mingyang, Yang, Xue, Wang, Dongsen, Wu, Qingjian. 2023. Association between the SLC6A11 rs2304725 and GABRG2 rs211037 polymorphisms and drug-resistant epilepsy: a meta-analysis. In Frontiers in physiology, 14, 1191927. doi:10.3389/fphys.2023.1191927. https://pubmed.ncbi.nlm.nih.gov/37275237/
2. Son, Woo-Young, Lee, Heon-Jeong, Yoon, Ho-Kyoung, Seo, Han-Kyu, Kim, Leen. 2013. Gaba transporter SLC6A11 gene polymorphism associated with tardive dyskinesia. In Nordic journal of psychiatry, 68, 123-8. doi:10.3109/08039488.2013.780260. https://pubmed.ncbi.nlm.nih.gov/23795861/
3. Xie, Y Y, Qu, J, Zhou, L, Long, H Y, Xiao, B. . Lack of Association between SLC6A11 Genetic Polymorphisms and Drug Resistant Epilepsy in Chinese Han Population. In Clinical laboratory, 63, 1113-1120. doi:10.7754/Clin.Lab.2017.161217. https://pubmed.ncbi.nlm.nih.gov/28792706/
4. Zhou, Yun, Danbolt, Niels Christian. 2013. GABA and Glutamate Transporters in Brain. In Frontiers in endocrinology, 4, 165. doi:10.3389/fendo.2013.00165. https://pubmed.ncbi.nlm.nih.gov/24273530/
5. Narang, Ankita, Lacaze, Paul, Ronaldson, Kathlyn J, Pantelis, Christos, Bousman, Chad A. 2022. Whole-genome sequencing analysis of clozapine-induced myocarditis. In The pharmacogenomics journal, 22, 173-179. doi:10.1038/s41397-022-00271-x. https://pubmed.ncbi.nlm.nih.gov/35461379/
6. Bhatt, Manan, Gauthier-Manuel, Laure, Lazzarin, Erika, Stockner, Thomas, Bossi, Elena. 2023. A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain. In Frontiers in physiology, 14, 1145973. doi:10.3389/fphys.2023.1145973. https://pubmed.ncbi.nlm.nih.gov/37123280/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen