C57BL/6JCya-Hcrtr1em1flox/Cya
Common Name
Hcrtr1-flox
Product ID
S-CKO-18002
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-230777-Hcrtr1-B6J-VB
When using this mouse strain in a publication, please cite “Hcrtr1-flox Mouse (Catalog S-CKO-18002) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Hcrtr1-flox
Strain ID
CKOCMP-230777-Hcrtr1-B6J-VB
Gene Name
Product ID
S-CKO-18002
Gene Alias
Ox1r, ox-1-R, ox1-R
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000030562
NCBI RefSeq
NM_198959
Target Region
Exon 5~7
Size of Effective Region
~3.5 kb
Overview of Gene Research
Hcrtr1, also known as OX1R, is a G-protein-coupled receptor. The endogenous ligands for Hcrtr1 are hypocretin/orexin neuropeptides. Hcrtr1 is associated with the regulation of motivation, reward, and autonomic functions, and is involved in the sleep-wake regulatory circuitry [1].
Hcrtr1 null mice displayed a significant reduction in behavioral despair in the forced swim test and tail suspension test, suggesting that Hcrtr1 signaling may have a role in modulating depression-like behaviors [4]. Also, a high-fat diet may induce depression-like phenotypes via hypocretin-Hcrtr1 mediated inflammation activation, and the Hcrtr1 antagonist SB334867 could reverse some adverse effects [3]. Moreover, an Hcrtr1 gene variant (rs2271933 G > A) has been associated with aggressive behavior, with Hcrtr1 A/A homozygotes showing higher aggression, and this genotype effect was dependent on the experience of stressful life events [2].
In conclusion, Hcrtr1 is crucial for functions related to motivation, reward, and autonomic activities. Research using Hcrtr1 knockout mouse models has revealed its significance in depression-like behaviors and aggressive behavior. Understanding Hcrtr1 may provide insights into the mechanisms of related mental disorders and potentially lead to new treatment strategies.
References：
1. Sun, Yu, Tisdale, Ryan K, Kilduff, Thomas S. 2021. Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. In Frontiers of neurology and neuroscience, 45, 22-37. doi:10.1159/000514963. https://pubmed.ncbi.nlm.nih.gov/34052813/
2. Harro, Jaanus, Laas, Kariina, Eensoo, Diva, Mäestu, Jarek, Veidebaum, Toomas. 2019. Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour. In Neuropharmacology, 156, 107527. doi:10.1016/j.neuropharm.2019.02.009. https://pubmed.ncbi.nlm.nih.gov/30742846/
3. Dong, Jingyi, Zhang, Jinghui, Cheng, Shangping, Zhang, Yuyan, Lu, Jing. 2024. A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation. In Food & function, 15, 8661-8673. doi:10.1039/d4fo00210e. https://pubmed.ncbi.nlm.nih.gov/39056112/
4. Scott, Michael M, Marcus, Jacob N, Pettersen, Ami, Elmquist, Joel K, Lutter, Michael. 2011. Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. In Behavioural brain research, 222, 289-94. doi:10.1016/j.bbr.2011.02.044. https://pubmed.ncbi.nlm.nih.gov/21377495/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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