Mapk8, also known as mitogen-activated protein kinase 8, is a key component in cell signaling pathways. It is involved in the JNK (c-Jun N-terminal kinase) signaling pathway, which plays a crucial role in regulating various cellular processes such as cell differentiation, apoptosis, and immune response [2,3,4,5].

In intervertebral disc degeneration (IDD), Mapk8 was identified as a key biomarker along with CAPN1. Bioinformatics analysis and qPCR validation in a rat IDD model showed its potential as a therapeutic target for IDD [1].

In the context of chicken male germ cell differentiation, knockdown/overexpression of Mapk8 affected the differentiation of embryonic stem cells into spermatogonial stem cells by inhibiting/activating the JNK signal [3].

In glioblastoma cells, over-expression of Mapk8 activated the MAPK signaling pathway, promoting resistance to temozolomide, accelerating cell proliferation, and inhibiting apoptosis. Conversely, inhibition of Mapk8 restrained colony formation and induced apoptosis [5].

In conclusion, Mapk8 is essential in regulating multiple biological processes through its involvement in the JNK and MAPK signaling pathways. Studies using models such as the rat IDD model and in vitro glioblastoma cell models have revealed its significance in diseases like IDD and glioblastoma, suggesting it could be a potential therapeutic target in these disease areas.