C57BL/6JCya-Serpinc1em1flox/Cya
Common Name:
Serpinc1-flox
Product ID:
S-CKO-18064
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Serpinc1-flox
Strain ID
CKOCMP-11905-Serpinc1-B6J-VB
Gene Name
Product ID
S-CKO-18064
Gene Alias
ATIII; At-3; At3
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
1
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Serpinc1em1flox/Cya mice (Catalog S-CKO-18064) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000064725
NCBI RefSeq
NM_080844.5
Target Region
Exon 3
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
SerpinC1, also known as the gene encoding antithrombin III (ATIII), is a serine protease inhibitor. ATIII has anticoagulant and anti-inflammatory actions. It is a key coagulation factor inhibitor, with even minor changes in ATIII significantly altering the risk of thromboembolism. ATIII can suppress inflammation via coagulation-dependent or-independent effects and is involved in multiple physiological and pathological processes [1].
SerpinC1 has been associated with various diseases. In kidney-related diseases, ATIII encoded by SerpinC1 affects the progress of kidney disease, though further studies are needed on its impact on renal function and treatment [1]. In colon cancer, SerpinC1 promotes cancer progression through epithelial-mesenchymal transition (EMT), is related to TNM stage and prognosis, and reduces the sensitivity to immune checkpoint therapy [2]. Congenital or acquired SerpinC1 deficiencies are risk factors for thromboembolic disease, and oral contraceptive use can lead to acquired SerpinC1 deficiency [3]. In lupus nephritis, urine SerpinC1 may be a biomarker for early detection [4]. Mutations in SerpinC1 are associated with antithrombin deficiency, and the SerpinC1 gene test is useful in determining the cause of AT-deficiency-related arterial thrombosis, especially ischemic stroke [5,6]. In preeclampsia, lower SerpinC1 levels in early-onset preeclampsia may be related to the disease, and it could be a potential early-diagnosis marker [7].
In conclusion, SerpinC1, through encoding ATIII, plays crucial roles in anticoagulation, anti-inflammation, and is involved in multiple disease processes such as kidney diseases, colon cancer, thromboembolic diseases, lupus nephritis, and preeclampsia. Understanding SerpinC1's functions and its associated mutations through various studies helps in revealing disease mechanisms and may potentially lead to new diagnostic and therapeutic strategies.
References:
1. Lu, Zeyuan, Wang, Feng, Liang, Mingyu. . SerpinC1/Antithrombin III in kidney-related diseases. In Clinical science (London, England : 1979), 131, 823-831. doi:10.1042/CS20160669. https://pubmed.ncbi.nlm.nih.gov/28424376/
2. Le, Zhenghong, Chen, Shuran, Feng, Yan, Lu, Weichen, Liu, Mulin. . SERPINC1, a new prognostic predictor of colon cancer, promote colon cancer progression through EMT. In Cancer reports (Hoboken, N.J.), 7, e2079. doi:10.1002/cnr2.2079. https://pubmed.ncbi.nlm.nih.gov/38923313/
3. Denora, D, Di Rosa, M V, Altamura, N, Fiotti, N, Biolo, G. 2023. Acquired SERPINC1/antithrombin deficiency during oral contraceptive consumption: a case report. In Journal of medical case reports, 17, 323. doi:10.1186/s13256-023-04038-1. https://pubmed.ncbi.nlm.nih.gov/37501065/
4. Kim, Young-Eun, Lee, Eun-Ju, Kim, Kyunggon, Yoo, Bin, Kim, Yong-Gil. 2023. Urine SERPINC1/ORM1 as biomarkers for early detection of lupus nephritis in MRL-lpr mice. In Frontiers in immunology, 14, 1148574. doi:10.3389/fimmu.2023.1148574. https://pubmed.ncbi.nlm.nih.gov/37744355/
5. Mulder, René, Croles, F Nanne, Mulder, André B, Meijer, Karina, Lukens, Michaël V. 2017. SERPINC1 gene mutations in antithrombin deficiency. In British journal of haematology, 178, 279-285. doi:10.1111/bjh.14658. https://pubmed.ncbi.nlm.nih.gov/28317092/
6. Kim, Seondeuk, Lee, Woo-Jin, Moon, Jangsup, Jung, Keun-Hwa. 2022. Utility of the SERPINC1 Gene Test in Ischemic Stroke Patients With Antithrombin Deficiency. In Frontiers in neurology, 13, 841934. doi:10.3389/fneur.2022.841934. https://pubmed.ncbi.nlm.nih.gov/35720094/
7. Palalıoğlu, Rabia Merve, Erbiyik, Halil Ibrahim. 2023. Assessment of maternal serum SERPINC1, E-selectin, P-selectin, and RBP4 levels in pregnancies with early- and late-onset preeclampsia. In The journal of obstetrics and gynaecology research, 49, 870-882. doi:10.1111/jog.15532. https://pubmed.ncbi.nlm.nih.gov/36604828/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen