C57BL/6JCya-Igf2em1flox/Cya
Common Name:
Igf2-flox
Product ID:
S-CKO-18104
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Igf2-flox
Strain ID
CKOCMP-16002-Igf2-B6J-VB
Gene Name
Product ID
S-CKO-18104
Gene Alias
Igf-2; Igf-II; M6pr; Mpr; Peg2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Igf2em1flox/Cya mice (Catalog S-CKO-18104) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000121128
NCBI RefSeq
NM_010514
Target Region
Exon 2
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Igf2, insulin-like growth factor 2, is a paternally expressed growth-promoting gene. It plays a crucial role in embryonic growth and development, and also has implications in adult physiology. It is involved in multiple signaling pathways such as the IGF2-IGF1R pathway, which has been linked to cancer progression. The study of Igf2 knockout mouse models has been fundamental in understanding its functions [1].
Research on Igf2 mutations in humans has shown that they can lead to Silver-Russell syndrome (SRS) [2]. In cancer research, in colorectal cancer, CAF-derived IGF2 promotes tumor growth, migration, and invasion through the IGF2-IGF1R-YAP1 axis [3]. In adrenocortical carcinoma, IGF2 is a differentiating marker, and different concentrations of IGF2 influence cell proliferation, metabolism, and viability [4].
In conclusion, Igf2 is essential for growth and development. Its dysregulation can lead to various disorders. Mouse models, especially Igf2 knockout models, have been instrumental in uncovering its role in diseases like SRS and different types of cancers, enhancing our understanding of disease mechanisms and potentially paving the way for new therapeutic strategies.
References：
1. Sélénou, Céline, Brioude, Frédéric, Giabicani, Eloïse, Sobrier, Marie-Laure, Netchine, Irène. 2022. IGF2: Development, Genetic and Epigenetic Abnormalities. In Cells, 11, . doi:10.3390/cells11121886. https://pubmed.ncbi.nlm.nih.gov/35741015/
2. Masunaga, Yohei, Inoue, Takanobu, Yamoto, Kaori, Kagami, Masayo, Ogata, Tsutomu. . IGF2 Mutations. In The Journal of clinical endocrinology and metabolism, 105, . doi:10.1210/clinem/dgz034. https://pubmed.ncbi.nlm.nih.gov/31544945/
3. Zhang, Jinglin, Chen, Bonan, Li, Hui, Lo, Kwok Wai, Kang, Wei. 2022. Cancer-associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2-IGF1R and Hippo-YAP1 signaling pathways. In The Journal of pathology, 259, 205-219. doi:10.1002/path.6033. https://pubmed.ncbi.nlm.nih.gov/36373776/
4. Pereira, Sofia S, Monteiro, Mariana P, Costa, Madalena M, Jarak, Ivana, Pignatelli, Duarte. 2019. IGF2 role in adrenocortical carcinoma biology. In Endocrine, 66, 326-337. doi:10.1007/s12020-019-02033-5. https://pubmed.ncbi.nlm.nih.gov/31378849/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen