C57BL/6JCya-Tac1em1flox/Cya
Common Name:
Tac1-flox
Product ID:
S-CKO-18130
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Tac1-flox
Strain ID
CKOCMP-21333-Tac1-B6J-VB
Gene Name
Product ID
S-CKO-18130
Gene Alias
4930528L02Rik; NK-1; NK1; Nkna; PPT-A; PPTA; SP
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tac1em1flox/Cya mice (Catalog S-CKO-18130) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000185187
NCBI RefSeq
NM_009311
Target Region
Exon 3~6
Size of Effective Region
~3.2 kb
Detailed Document
Overview of Gene Research
Tac1, or tachykinin 1, has diverse functions. In animals, it is involved in neural circuits related to various behaviors and physiological responses. In plants, it contributes to regulating lateral shoot orientation. In animals, it plays roles in pathways such as those related to itch-scratching cycles, defensive responses, sexual behavior, social interactions, anhedonia-like behavior, and avoidance responses to aversive stimuli [1,2,3,4,6,7]. In plants, it opposes the influence of LAZY1 on lateral shoot orientation [5].
In mice, the ablation or suppression of Tac1-expressing neurons in the lateral and ventrolateral periaqueductal gray decreased itch-induced scratching behavior, suggesting that these neurons promote the itch-scratching cycle [1]. In the gut-to-brain axis, manipulation of the circuit involving Tac1+ neurons in the dorsal vagal complex interfered with toxin-induced defensive responses [2]. Ablation of spinal neurons expressing gastrin-releasing peptide receptor suppressed the scratching behavior evoked by Tac1-expressing neuron activation, indicating the importance of this neural connection in the itch-scratching cycle [1].
In conclusion, Tac1 is crucial in multiple biological processes, including those related to neural-mediated behaviors in animals and shoot architecture regulation in plants. Studies using mouse models, especially those involving manipulation of Tac1-expressing neurons, have revealed its role in various physiological and behavioral responses, which may provide insights into related disease conditions and plant growth regulation.
References:
1. Gao, Zheng-Run, Chen, Wen-Zhen, Liu, Ming-Zhe, Xu, Xiao-Hong, Sun, Yan-Gang. 2018. Tac1-Expressing Neurons in the Periaqueductal Gray Facilitate the Itch-Scratching Cycle via Descending Regulation. In Neuron, 101, 45-59.e9. doi:10.1016/j.neuron.2018.11.010. https://pubmed.ncbi.nlm.nih.gov/30554781/
2. Xie, Zhiyong, Zhang, Xianying, Zhao, Miao, Shang, Congping, Cao, Peng. 2022. The gut-to-brain axis for toxin-induced defensive responses. In Cell, 185, 4298-4316.e21. doi:10.1016/j.cell.2022.10.001. https://pubmed.ncbi.nlm.nih.gov/36323317/
3. Bayless, Daniel W, Davis, Chung-Ha O, Yang, Renzhi, Luo, Liqun, Shah, Nirao M. 2023. A neural circuit for male sexual behavior and reward. In Cell, 186, 3862-3881.e28. doi:10.1016/j.cell.2023.07.021. https://pubmed.ncbi.nlm.nih.gov/37572660/
4. Yu, Hang, Miao, Wanying, Ji, En, Xu, Fuqiang, Yu, Xiang. 2022. Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions. In Neuron, 110, 1051-1067.e7. doi:10.1016/j.neuron.2021.12.022. https://pubmed.ncbi.nlm.nih.gov/35045339/
5. Hollender, Courtney A, Hill, Joseph L, Waite, Jessica, Dardick, Chris. 2020. Opposing influences of TAC1 and LAZY1 on Lateral Shoot Orientation in Arabidopsis. In Scientific reports, 10, 6051. doi:10.1038/s41598-020-62962-4. https://pubmed.ncbi.nlm.nih.gov/32269265/
6. He, Zi-Xuan, Yin, Yue-Yue, Xi, Ke, Yu, Hua-Li, Zhu, Xiao-Juan. . Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice. In Cell reports, 33, 108343. doi:10.1016/j.celrep.2020.108343. https://pubmed.ncbi.nlm.nih.gov/33147466/
7. He, Zi-Xuan, Xi, Ke, Liu, Kai-Jie, Xing, Zhen-Kai, Zhu, Xiao-Juan. 2023. A Nucleus Accumbens Tac1 Neural Circuit Regulates Avoidance Responses to Aversive Stimuli. In International journal of molecular sciences, 24, . doi:10.3390/ijms24054346. https://pubmed.ncbi.nlm.nih.gov/36901777/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen