C57BL/6JCya-Serpinf1em1flox/Cya
Common Name
Serpinf1-flox
Product ID
S-CKO-18177
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-20317-Serpinf1-B6J-VB
When using this mouse strain in a publication, please cite “Serpinf1-flox Mouse (Catalog S-CKO-18177) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Serpinf1-flox
Strain ID
CKOCMP-20317-Serpinf1-B6J-VB
Gene Name
Product ID
S-CKO-18177
Gene Alias
EPC-1, Pedf, Pedfl, Sdf3
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000000769
NCBI RefSeq
NM_011340
Target Region
Exon 3
Size of Effective Region
~0.7 kb
Overview of Gene Research
Serpinf1, encoding pigment epithelium-derived factor (PEDF), is a member of the serpin family but lacks typical serine protease inhibitory activity. It has anti-tumor, anti-angiogenesis, anti-inflammation, nutrition and nerve protection functions, and is involved in fat metabolism [2].
In glioma, higher Serpinf1 expression correlates with poor overall survival. Knockdown of Serpinf1 suppresses glioma cell proliferation, invasion, migration and impairs the sphere formation of glioma stem cells. Bioinformatics analysis shows Notch signaling activation is associated with high Serpinf1 expression, and STAT1, CREM, and NR2F2 may participate in its transcriptional regulation [1].
In osteogenesis imperfecta type VI, Serpinf1 mutations lead to severe progressive deforming phenotypes. Homozygous in-frame deletions or insertions in Serpinf1 cause retention or degradation of PEDF within cellular compartments, interfering with its secretion [3].
In conclusion, Serpinf1 has diverse functions in different biological processes and diseases. In glioma, it may serve as a prognostic predictor and therapeutic target. In osteogenesis imperfecta type VI, its mutations disrupt normal PEDF secretion and cause bone-related phenotypes. These findings from functional studies help understand the role of Serpinf1 in disease development and potentially guide treatment strategies.
References：
1. Song, Lairong, Huo, Xulei, Li, Xiaojie, Wang, Liang, Wu, Zhen. 2023. SERPINF1 Mediates Tumor Progression and Stemness in Glioma. In Genes, 14, . doi:10.3390/genes14030580. https://pubmed.ncbi.nlm.nih.gov/36980858/
2. Zhang, Chao, Yang, Wei, Zhang, Shanshan, Li, Mian, Lu, Yanqin. . Pan-cancer analysis of osteogenesis imperfecta causing gene SERPINF1. In Intractable & rare diseases research, 11, 15-24. doi:10.5582/irdr.2021.01138. https://pubmed.ncbi.nlm.nih.gov/35261846/
3. Al-Jallad, Hadil, Palomo, Telma, Roughley, Peter, Moffatt, Pierre, Rauch, Frank. 2015. The effect of SERPINF1 in-frame mutations in osteogenesis imperfecta type VI. In Bone, 76, 115-20. doi:10.1016/j.bone.2015.04.008. https://pubmed.ncbi.nlm.nih.gov/25868797/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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