C57BL/6JCya-Mroh9em1flox/Cya
Common Name:
Mroh9-flox
Product ID:
S-CKO-18179
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mroh9-flox
Strain ID
CKOCMP-78258-Mroh9-B6J-VB
Gene Name
Product ID
S-CKO-18179
Gene Alias
4921528O07Rik; Armc11
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
1
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mroh9em1flox/Cya mice (Catalog S-CKO-18179) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000096608
NCBI RefSeq
NM_030071
Target Region
Exon 8
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
Mroh9 is a gene whose functions and associations are being explored in biomedical research. Although its exact essential function, associated pathways, and overall biological importance are not comprehensively detailed in the provided references, studies suggest its potential involvement in multiple biological contexts.
In a study on lung cancer patients with chronic obstructive pulmonary disease, hsa-MROH9_0001, a circular RNA related to Mroh9, was identified. It was positively correlated with plasma cells, and the two DEcircRNA-sponged miRNAs it was associated with showed good diagnostic performance. This indicates its potential as a therapeutic target in this disease context [1].
In pancreatic adenocarcinoma, MROH9 was among genes potentially related to the oncology process, suggesting its possible role in this deadly digestive system tumor [2].
Additionally, in the study of giant cell arteritis, positional gene mapping of an associated transient ischaemic attack Polygenic Risk Score identified the MROH9 locus, hinting at its possible role in immune and coagulation-related pathways in the pathogenesis of cranial ischaemic complications [3].
In conclusion, Mroh9 appears to be implicated in various disease conditions such as lung cancer with COPD, pancreatic adenocarcinoma, and in the pathogenesis of cranial ischaemic complications in giant cell arteritis. Although direct gene-knockout or conditional-knockout mouse model-based findings are not presented in the provided references, these studies highlight its potential significance in understanding disease mechanisms and developing potential therapeutic strategies.
References:
1. Li, Xiaoou, Shen, Yongchun, Cheng, Jiahan, Liu, Lunxu, Wen, Fuqiang. . Differential expression profiles and functional prediction of circular RNAs in lung cancer patients with chronic obstructive pulmonary disease: a pilot study. In General physiology and biophysics, 43, 273-289. doi:10.4149/gpb_2024013. https://pubmed.ncbi.nlm.nih.gov/38953571/
2. Wu, Zixuan, Huang, Xuyan, Cai, Minjie, Huang, Peidong, Guan, Zunhui. 2022. Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma. In Aging, 14, 869-891. doi:10.18632/aging.203846. https://pubmed.ncbi.nlm.nih.gov/35077391/
3. Chaddock, Natalie J M, Harden, Charlotte J, Sorensen, Louise, Iles, Mark M, Morgan, Ann W. 2025. Age, anticoagulants, hypertension and cardiovascular genetic traits predict cranial ischaemic complications in patients with giant cell arteritis. In Annals of the rheumatic diseases, 84, 329-340. doi:10.1136/ard-2024-225515. https://pubmed.ncbi.nlm.nih.gov/39919905/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen