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C57BL/6JCya-Crip1em1flox/Cya
Common Name:
Crip1-flox
Product ID:
S-CKO-18201
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Crip1-flox
Strain ID
CKOCMP-12925-Crip1-B6J-VA
Gene Name
Crip1
Product ID
S-CKO-18201
Gene Alias
CRHP; CRP1; Crip
Background
C57BL/6JCya
NCBI ID
12925
Modification
Conditional knockout
Chromosome
12
Phenotype
MGI:88501
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Crip1em1flox/Cya mice (Catalog S-CKO-18201) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000006523
NCBI RefSeq
NM_007763
Target Region
Exon 2~5
Size of Effective Region
~1.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
CRIP1, also known as cysteine-rich intestinal protein 1, encodes a member of the LIM/double zinc finger protein family. It is involved in regulating diverse cellular processes such as cell growth, development, and differentiation. CRIP1 is associated with multiple signaling pathways including NF-κB, Wnt/β-catenin, and is important in maintaining protein homeostasis [1,2,5,7]. Genetic models, especially KO/CKO mouse models, could potentially offer insights into its functions.

In pancreatic ductal adenocarcinoma (PDAC), CRIP1 upregulation fosters MDSC trafficking and an immunosuppressive tumor microenvironment by facilitating NF-κB/p65 nuclear translocation [1]. In hepatocellular carcinoma (HCC), it promotes cancer stem-like properties by suppressing BBOX1-mediated carnitine metabolism [2]. In gastric cancer, CRIP1 overexpression promotes lymphangiogenesis and lymphatic metastasis by phosphorylating CREB1 and regulating VEGFC and CCL5 expression [3]. In multiple myeloma, high CRIP1 expression is linked to unfavorable outcomes, and it dual-regulates proteasome and autophagy activities [4]. In osteoporosis, reduced CRIP1 expression in bone marrow stromal cells (BMSCs) impairs osteogenic differentiation, while overexpression enhances it via the Wnt signaling pathway [5]. In acute myeloid leukemia (AML), high CRIP1 expression is related to lower remission rates and shorter survival, and in AML-M5 subtype cells, it supports growth and migration by activating the Wnt/β-catenin pathway [6,7]. In gastric cancer, CRIP1 promotes homologous repair upon DNA damage from chemotherapy by cooperating with BRCA2 to enrich nuclear RAD51 [8].

In conclusion, CRIP1 is a crucial regulator in various biological processes and diseases. Through model-based research, its roles in tumorigenesis, immune regulation, bone metabolism, and leukemia development have been revealed. The use of KO/CKO mouse models could further clarify its functions in these disease areas, providing potential therapeutic targets for PDAC, HCC, gastric cancer, multiple myeloma, osteoporosis, and AML.

References:
1. Liu, Xiaomeng, Tang, Rong, Xu, Jin, Yu, Xianjun, Shi, Si. 2023. CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-κB/p65 nuclear translocation in pancreatic ductal adenocarcinoma. In Gut, 72, 2329-2343. doi:10.1136/gutjnl-2022-329349. https://pubmed.ncbi.nlm.nih.gov/37541772/
2. Wang, Jing, Zhou, Yan, Zhang, Donghui, Wang, Hui, Zhao, Liang. 2022. CRIP1 suppresses BBOX1-mediated carnitine metabolism to promote stemness in hepatocellular carcinoma. In The EMBO journal, 41, e110218. doi:10.15252/embj.2021110218. https://pubmed.ncbi.nlm.nih.gov/35775648/
3. Wu, Zhonghua, Qu, Bicheng, Yuan, Minxian, Song, Yongxi, Wang, Zhenning. 2023. CRIP1 Reshapes the Gastric Cancer Microenvironment to Facilitate Development of Lymphatic Metastasis. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10, e2303246. doi:10.1002/advs.202303246. https://pubmed.ncbi.nlm.nih.gov/37409440/
4. Tang, Peixia, Yu, Zhen, Sun, Hao, Qiu, Lugui, Hao, Mu. 2024. CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy. In EBioMedicine, 100, 104961. doi:10.1016/j.ebiom.2023.104961. https://pubmed.ncbi.nlm.nih.gov/38199044/
5. Chen, Ruge, Jin, Yangchen, Lian, Ru, Zhang, Zhongmin, Zhao, Liang. 2024. CRIP1 regulates osteogenic differentiation of bone marrow stromal cells and pre-osteoblasts via the Wnt signaling pathway. In Biochemical and biophysical research communications, 727, 150277. doi:10.1016/j.bbrc.2024.150277. https://pubmed.ncbi.nlm.nih.gov/38936225/
6. Ma, Bei-Bei, Zhang, Ting-Juan, Wang, Cui-Zhu, Lin, Jiang, Qian, Jun. 2020. Methylation-independent CRIP1 expression is a potential biomarker affecting prognosis in cytogenetically normal acute myeloid leukemia. In American journal of translational research, 12, 4840-4852. doi:. https://pubmed.ncbi.nlm.nih.gov/33042393/
7. Deng, Xiaoling, Zeng, Yanmei, Qiu, Xiaofen, Zhang, Jingdong, Chen, Xiaoli. 2023. CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway. In Leukemia research, 130, 107312. doi:10.1016/j.leukres.2023.107312. https://pubmed.ncbi.nlm.nih.gov/37224580/
8. Sun, Huiying, Zhou, Rui, Zheng, Yannan, Shi, Min, Liao, Wangjun. 2021. CRIP1 cooperates with BRCA2 to drive the nuclear enrichment of RAD51 and to facilitate homologous repair upon DNA damage induced by chemotherapy. In Oncogene, 40, 5342-5355. doi:10.1038/s41388-021-01932-0. https://pubmed.ncbi.nlm.nih.gov/34262130/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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