C57BL/6JCya-Serpind1em1flox/Cya
Common Name
Serpind1-flox
Product ID
S-CKO-18213
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-15160-Serpind1-B6J-VB
When using this mouse strain in a publication, please cite “Serpind1-flox Mouse (Catalog S-CKO-18213) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Serpind1-flox
Strain ID
CKOCMP-15160-Serpind1-B6J-VB
Gene Name
Product ID
S-CKO-18213
Gene Alias
HC-II, HCII, Hcf2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 16
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000023450
NCBI RefSeq
NM_008223
Target Region
Exon 3~5
Size of Effective Region
~4.7 kb
Overview of Gene Research
Serpind1, also known as heparin cofactor II, is a member of the serine protease inhibitor family. It is involved in modulating coagulation and can interact with glycosaminoglycans (GAGs) to enhance protease inhibition [3]. Some serpins utilize GAGs like heparin and heparan sulfate to achieve maximal protease inhibition, and Serpind1 is one of them [3].
In epithelial ovarian cancer, Serpind1 expression is significantly elevated. High Serpind1 expression is associated with poor prognosis. It promotes cancer cell proliferation, migration, invasion, G1-to-S phase transition, and epithelial-mesenchymal transition, while inhibiting apoptosis through promoting phosphorylation in the PI3K/AKT pathway [1].
In papillary thyroid carcinoma, Serpind1 was identified as a biomarker related to SUMOylation, with gene set enrichment analysis showing its involvement in immune-related pathways [2].
In glaucoma, Serpind1 is significantly upregulated and may play a vital role in glaucoma occurrences, associated with eye transparency decrease and glucose metabolism [4].
In systemic sclerosis-associated pulmonary hypertension, higher levels of Serpind1 were associated with better survival in patients [5].
In melanoma, proteins including Serpind1 in plasma-derived extracellular vesicles were identified as relevant in differentiating between disease stages [6].
In intrahepatic cholestasis of pregnancy, Serpind1 expression levels were remarkably lower in patients compared to healthy pregnant controls, and it had a negative correlation with total bile acid [7].
In atherosclerosis, miR-155 induced by polycyclic aromatic hydrocarbons downregulates Serpind1, accelerating the development of arteriosclerosis [8].
In conclusion, Serpind1 is an important serine protease inhibitor involved in multiple biological processes and diseases. Its role in modulating coagulation through GAG-binding is well-established. In various cancers, glaucoma, pregnancy-related conditions, and atherosclerosis, Serpind1 shows differential expression patterns and impacts disease progression. Understanding Serpind1's function provides insights into disease mechanisms and potential therapeutic targets.
References：
1. Guo, Qian, Zhu, Liancheng, Wang, Caixia, Li, Xiao, Lin, Bei. 2019. SERPIND1 Affects the Malignant Biological Behavior of Epithelial Ovarian Cancer via the PI3K/AKT Pathway: A Mechanistic Study. In Frontiers in oncology, 9, 954. doi:10.3389/fonc.2019.00954. https://pubmed.ncbi.nlm.nih.gov/31637210/
2. Li, Xiang, Ding, Zigang, Tong, Yun. 2024. Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma. In Cancer cell international, 24, 149. doi:10.1186/s12935-024-03323-3. https://pubmed.ncbi.nlm.nih.gov/38671425/
3. Rein, Chantelle M, Desai, Umesh R, Church, Frank C. . Serpin-glycosaminoglycan interactions. In Methods in enzymology, 501, 105-37. doi:10.1016/B978-0-12-385950-1.00007-9. https://pubmed.ncbi.nlm.nih.gov/22078533/
4. Liu, Xiaoyan, Liu, Xiang, Wang, Ying, Xu, Jiyu, Sun, Wei. 2021. Proteome Characterization of Glaucoma Aqueous Humor. In Molecular & cellular proteomics : MCP, 20, 100117. doi:10.1016/j.mcpro.2021.100117. https://pubmed.ncbi.nlm.nih.gov/34214668/
5. Mismetti, Valentine, Delavenne, Xavier, Montani, David, Bertoletti, Laurent, Cottin, Vincent. 2023. Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension. In Respiratory research, 24, 273. doi:10.1186/s12931-023-02578-0. https://pubmed.ncbi.nlm.nih.gov/37936223/
6. Bollard, S M, Howard, J, Casalou, C, McCann, A, Potter, S M. 2024. Proteomic and metabolomic profiles of plasma-derived Extracellular Vesicles differentiate melanoma patients from healthy controls. In Translational oncology, 50, 102152. doi:10.1016/j.tranon.2024.102152. https://pubmed.ncbi.nlm.nih.gov/39405606/
7. Chen, Lingyan, Li, Jingyang, You, Yilan, Xiao, Jianping, Zhang, Yan. 2023. Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study. In Heliyon, 9, e21616. doi:10.1016/j.heliyon.2023.e21616. https://pubmed.ncbi.nlm.nih.gov/38027820/
8. He, Xiao-Nan, Xin, Jin-Yuan, Zhan, Jin-Liang, Zhang, Xiao-Ling, Bai, Ying-Chen. 2021. Polycyclic aromatic hydrocarbons induce endothelial injury through miR-155 to promote atherosclerosis. In Environmental and molecular mutagenesis, 62, 409-421. doi:10.1002/em.22454. https://pubmed.ncbi.nlm.nih.gov/34331478/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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