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C57BL/6JCya-Serpind1em1flox/Cya
Common Name:
Serpind1-flox
Product ID:
S-CKO-18213
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Serpind1-flox
Strain ID
CKOCMP-15160-Serpind1-B6J-VB
Gene Name
Serpind1
Product ID
S-CKO-18213
Gene Alias
HC-II; HCII; Hcf2
Background
C57BL/6JCya
NCBI ID
15160
Modification
Conditional knockout
Chromosome
16
Phenotype
MGI:96051
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Serpind1em1flox/Cya mice (Catalog S-CKO-18213) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023450
NCBI RefSeq
NM_008223
Target Region
Exon 3~5
Size of Effective Region
~4.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Serpind1, also known as heparin cofactor II, is a member of the serine protease inhibitor family. It is involved in modulating coagulation and can interact with glycosaminoglycans (GAGs) to enhance protease inhibition [3]. Some serpins utilize GAGs like heparin and heparan sulfate to achieve maximal protease inhibition, and Serpind1 is one of them [3].

In epithelial ovarian cancer, Serpind1 expression is significantly elevated. High Serpind1 expression is associated with poor prognosis. It promotes cancer cell proliferation, migration, invasion, G1-to-S phase transition, and epithelial-mesenchymal transition, while inhibiting apoptosis through promoting phosphorylation in the PI3K/AKT pathway [1].

In papillary thyroid carcinoma, Serpind1 was identified as a biomarker related to SUMOylation, with gene set enrichment analysis showing its involvement in immune-related pathways [2].

In glaucoma, Serpind1 is significantly upregulated and may play a vital role in glaucoma occurrences, associated with eye transparency decrease and glucose metabolism [4].

In systemic sclerosis-associated pulmonary hypertension, higher levels of Serpind1 were associated with better survival in patients [5].

In melanoma, proteins including Serpind1 in plasma-derived extracellular vesicles were identified as relevant in differentiating between disease stages [6].

In intrahepatic cholestasis of pregnancy, Serpind1 expression levels were remarkably lower in patients compared to healthy pregnant controls, and it had a negative correlation with total bile acid [7].

In atherosclerosis, miR-155 induced by polycyclic aromatic hydrocarbons downregulates Serpind1, accelerating the development of arteriosclerosis [8].

In conclusion, Serpind1 is an important serine protease inhibitor involved in multiple biological processes and diseases. Its role in modulating coagulation through GAG-binding is well-established. In various cancers, glaucoma, pregnancy-related conditions, and atherosclerosis, Serpind1 shows differential expression patterns and impacts disease progression. Understanding Serpind1's function provides insights into disease mechanisms and potential therapeutic targets.

References:
1. Guo, Qian, Zhu, Liancheng, Wang, Caixia, Li, Xiao, Lin, Bei. 2019. SERPIND1 Affects the Malignant Biological Behavior of Epithelial Ovarian Cancer via the PI3K/AKT Pathway: A Mechanistic Study. In Frontiers in oncology, 9, 954. doi:10.3389/fonc.2019.00954. https://pubmed.ncbi.nlm.nih.gov/31637210/
2. Li, Xiang, Ding, Zigang, Tong, Yun. 2024. Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma. In Cancer cell international, 24, 149. doi:10.1186/s12935-024-03323-3. https://pubmed.ncbi.nlm.nih.gov/38671425/
3. Rein, Chantelle M, Desai, Umesh R, Church, Frank C. . Serpin-glycosaminoglycan interactions. In Methods in enzymology, 501, 105-37. doi:10.1016/B978-0-12-385950-1.00007-9. https://pubmed.ncbi.nlm.nih.gov/22078533/
4. Liu, Xiaoyan, Liu, Xiang, Wang, Ying, Xu, Jiyu, Sun, Wei. 2021. Proteome Characterization of Glaucoma Aqueous Humor. In Molecular & cellular proteomics : MCP, 20, 100117. doi:10.1016/j.mcpro.2021.100117. https://pubmed.ncbi.nlm.nih.gov/34214668/
5. Mismetti, Valentine, Delavenne, Xavier, Montani, David, Bertoletti, Laurent, Cottin, Vincent. 2023. Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension. In Respiratory research, 24, 273. doi:10.1186/s12931-023-02578-0. https://pubmed.ncbi.nlm.nih.gov/37936223/
6. Bollard, S M, Howard, J, Casalou, C, McCann, A, Potter, S M. 2024. Proteomic and metabolomic profiles of plasma-derived Extracellular Vesicles differentiate melanoma patients from healthy controls. In Translational oncology, 50, 102152. doi:10.1016/j.tranon.2024.102152. https://pubmed.ncbi.nlm.nih.gov/39405606/
7. Chen, Lingyan, Li, Jingyang, You, Yilan, Xiao, Jianping, Zhang, Yan. 2023. Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study. In Heliyon, 9, e21616. doi:10.1016/j.heliyon.2023.e21616. https://pubmed.ncbi.nlm.nih.gov/38027820/
8. He, Xiao-Nan, Xin, Jin-Yuan, Zhan, Jin-Liang, Zhang, Xiao-Ling, Bai, Ying-Chen. 2021. Polycyclic aromatic hydrocarbons induce endothelial injury through miR-155 to promote atherosclerosis. In Environmental and molecular mutagenesis, 62, 409-421. doi:10.1002/em.22454. https://pubmed.ncbi.nlm.nih.gov/34331478/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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