C57BL/6JCya-Fmo1em1flox/Cya
Common Name:
Fmo1-flox
Product ID:
S-CKO-18315
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fmo1-flox
Strain ID
CKOCMP-14261-Fmo1-B6J-VB
Gene Name
Product ID
S-CKO-18315
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
1
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fmo1em1flox/Cya mice (Catalog S-CKO-18315) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000046049
NCBI RefSeq
NM_010231
Target Region
Exon 3~4
Size of Effective Region
~2.8 kb
Detailed Document
Overview of Gene Research
Fmo1, flavin containing dimethylaniline monooxygenase 1, is involved in lipid metabolism [2]. It is also one of the genes defining major fibroblast populations in human skin [1]. In plants like Arabidopsis thaliana, its homolog is a regulator in plant resistance and systemic acquired acclimation [4].
In a cellular non-alcoholic fatty liver disease (NAFLD) model, knockdown of Fmo1 suppressed lipid accumulation, reversed the down-regulation of PPARα expression, and reduced ferroptosis upregulation induced by free fatty acids. In contrast, Fmo1 overexpression dysregulated lipid metabolism and downregulated PPARα levels. PPARα overexpression mitigated the Fmo1-overexpression-induced upregulation of ferroptosis and lipid accumulation [2]. High Fmo1 expression in classical papillary thyroid cancer independently predicted favorable recurrence-free survival [3].
In conclusion, Fmo1 plays a significant role in lipid metabolism, as demonstrated by in vitro NAFLD models, and has prognostic value in classical papillary thyroid cancer. Understanding Fmo1 function through such models can provide insights into related disease mechanisms and potential treatment strategies.
References：
1. Tabib, Tracy, Morse, Christina, Wang, Ting, Chen, Wei, Lafyatis, Robert. 2017. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin. In The Journal of investigative dermatology, 138, 802-810. doi:10.1016/j.jid.2017.09.045. https://pubmed.ncbi.nlm.nih.gov/29080679/
2. Zou, Lin, Shi, Qin, Li, Yingxuan, Zhu, Hongling, Ma, Junhua. . FMO1 Promotes Nonalcoholic Fatty Liver Disease Progression by Regulating PPARα Activation and Inducing Ferroptosis. In Discovery medicine, 35, 612-622. doi:10.24976/Discov.Med.202335177.60. https://pubmed.ncbi.nlm.nih.gov/37553313/
3. Luo, Jing, Zhang, Bowei, Cui, Likun, Liu, Tong, Gu, Yi. 2019. FMO1 gene expression independently predicts favorable recurrence-free survival of classical papillary thyroid cancer. In Future oncology (London, England), 15, 1303-1311. doi:10.2217/fon-2018-0885. https://pubmed.ncbi.nlm.nih.gov/30757917/
4. Czarnocka, Weronika, Fichman, Yosef, Bernacki, Maciej, Mittler, Ron, Karpiński, Stanisław. 2020. FMO1 Is Involved in Excess Light Stress-Induced Signal Transduction and Cell Death Signaling. In Cells, 9, . doi:10.3390/cells9102163. https://pubmed.ncbi.nlm.nih.gov/32987853/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen