C57BL/6JCya-Cacng3em1flox/Cya
Common Name:
Cacng3-flox
Product ID:
S-CKO-18421
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Cacng3-flox
Strain ID
CKOCMP-54376-Cacng3-B6J-VB
Gene Name
Product ID
S-CKO-18421
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cacng3em1flox/Cya mice (Catalog S-CKO-18421) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000084615
NCBI RefSeq
NM_019430
Target Region
Exon 1
Size of Effective Region
~2.8 kb
Detailed Document
Overview of Gene Research
Cacng3, also known as gamma-3 subunit of the voltage-gated calcium channel, is involved in synaptic transmission, a crucial process for communication between neurons [1]. Genes encoding brain-expressed voltage-gated calcium channels, including Cacng3, may contribute to the genetic susceptibility of certain neurological disorders, highlighting its importance in neural function [2,4,5].
In glioma research, Cacng3 was expressed at low levels in the tumor group, and patients with low Cacng3 expression had shorter overall survival. Its expression was negatively associated with glioma grades, and it could serve as a biomarker for the mesenchymal molecular subtype. Functional annotation and pathway enrichment analysis suggested that Cacng3 might affect glioma development by interfering with synaptic transmission. Also, temozolomide increased Cacng3 expression in a dose and time-dependent manner [1].
In childhood absence epilepsy, linkage and association analysis supported Cacng3 as a susceptibility locus in a subset of patients, though no putative causal coding variants were identified upon re-sequencing [2].
In age-related macular degeneration, Cacng3 was the best candidate for an AMD risk gene within the 16p12 linkage peak [3].
In conclusion, Cacng3 plays a vital role in synaptic transmission and is associated with multiple diseases, such as glioma, childhood absence epilepsy, and age-related macular degeneration. The study of Cacng3 through genetic analysis in these disease models helps to understand its role in disease pathogenesis, potentially providing new targets for diagnosis and treatment.
References:
1. Shan, Enfang, Cao, Yi-Nan, Zhang, Yang, Zhi, Tongle, Li, Xianwen. 2023. Integrated profiling identifies CACNG3 as a prognostic biomarker for patients with glioma. In BMC cancer, 23, 846. doi:10.1186/s12885-023-10896-1. https://pubmed.ncbi.nlm.nih.gov/37697240/
2. Everett, Kate V, Chioza, Barry, Aicardi, Jean, Rees, Michele, Gardiner, Mark. 2007. Linkage and association analysis of CACNG3 in childhood absence epilepsy. In European journal of human genetics : EJHG, 15, 463-72. doi:. https://pubmed.ncbi.nlm.nih.gov/17264864/
3. Spencer, Kylee L, Olson, Lana M, Schnetz-Boutaud, Nathalie, Pericak-Vance, Margaret A, Haines, Jonathan L. 2011. Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility. In Investigative ophthalmology & visual science, 52, 1748-54. doi:10.1167/iovs.09-5112. https://pubmed.ncbi.nlm.nih.gov/21169531/
4. Yalçın, Ozlem. 2011. Genes and molecular mechanisms involved in the epileptogenesis of idiopathic absence epilepsies. In Seizure, 21, 79-86. doi:10.1016/j.seizure.2011.12.002. https://pubmed.ncbi.nlm.nih.gov/22206818/
5. Robinson, Robert, Taske, Nichole, Sander, Thomas, Rees, Michele, Gardiner, R Mark. . Linkage analysis between childhood absence epilepsy and genes encoding GABAA and GABAB receptors, voltage-dependent calcium channels, and the ECA1 region on chromosome 8q. In Epilepsy research, 48, 169-79. doi:. https://pubmed.ncbi.nlm.nih.gov/11904235/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen