Plek, or pleckstrin, is a gene whose exact function remains to be fully elucidated, but studies suggest its involvement in various biological processes. It has been associated with immune-related pathways, as seen in its enrichment in immune system processes according to gene ontology analysis [2].

Research on Plek has focused on its relationship with several diseases. In psoriasis complicated with atherosclerosis, Plek was identified as one of the 16 important hub genes, suggesting its role in the common pathogenesis of these two diseases [1]. In carotid atherosclerosis, Plek was among the 10 core genes obtained through protein-protein interaction network analysis, and its high expression was associated with carotid AS samples, indicating it could be a potential biomarker [2]. In non-small cell lung cancer, Plek was one of the 13 differentiation-related genes in tumor-associated macrophages related to prognosis, with its expression associated with a better prognosis in lung adenocarcinoma [3]. In addition, in venous thromboembolism, Plek was among the genetically regulated circulating protein abundances associated with the disease, and was suggested as a possible diagnostic and therapeutic target [4]. In multiple sclerosis, genetically predicted higher levels of Plek were associated with an increased risk of the disease, and Plek was identified as a druggable target gene [5].

In conclusion, Plek appears to play important roles in multiple disease conditions, especially those related to immune responses and atherosclerosis-related pathologies. Studies on Plek, potentially including gene knockout models in the future, could further clarify its biological functions and offer new insights for disease treatment and prevention in areas such as psoriasis-associated atherosclerosis, carotid atherosclerosis, non-small cell lung cancer, venous thromboembolism, and multiple sclerosis.