C57BL/6JCya-Trim2em1flox/Cya
Common Name
Trim2-flox
Product ID
S-CKO-18492
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-80890-Trim2-B6J-VB
When using this mouse strain in a publication, please cite “Trim2-flox Mouse (Catalog S-CKO-18492) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Trim2-flox
Strain ID
CKOCMP-80890-Trim2-B6J-VB
Gene Name
Product ID
S-CKO-18492
Gene Alias
mKIAA0517, narf
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000054990
NCBI RefSeq
NM_001271725
Target Region
Exon 2
Size of Effective Region
~1.3 kb
Overview of Gene Research
Trim2, also known as CMT2R or RNF86, is a member of the TRIM superfamily and functions as an E3 ubiquitin ligase. It is involved in multiple biological processes such as neuroprotection, antiviral responses, and plays diverse roles in cell evolution including intracellular signaling, apoptosis, and carcinogenesis [1].
Trim2-knockout mice (Trim2A/A) develop ataxia associated with loss of cerebellar Purkinje cells and a peripheral neuropathy, indicating that loss of Trim2 in these neurons has cell-autonomous effects on their axons [3]. Knocking out Trim2 in Vero E6 cells inhibits porcine epidemic diarrhea virus replication [2]. In a model of inflammation-induced angiogenesis, Trim2 -/- mice showed less adventitial macrophage infiltration and reduced adventitial proliferating neovessels, while in a hypoxia-mediated angiogenesis model, there were no differences in blood flow reperfusion between Trim2 -/- and wild-type mice [4].
In conclusion, Trim2 is a multifunctional gene involved in various biological processes and diseases. Gene-knockout mouse models have revealed its role in neurological diseases, viral infections, and angiogenesis. Understanding Trim2's functions can provide insights into the mechanisms of these diseases and potential therapeutic targets.
References：
1. Xiao, Maolin, Li, Jianjun, Liu, Qingyuan, Yang, Zongke, Wang, Delin. 2022. Expression and Role of TRIM2 in Human Diseases. In BioMed research international, 2022, 9430509. doi:10.1155/2022/9430509. https://pubmed.ncbi.nlm.nih.gov/36051486/
2. Wang, Jieru, Liu, Hailong, Yang, Yuqing, Wang, Chonglong, Xie, Shengsong. 2023. Genome-scale CRISPR screen identifies TRIM2 and SLC35A1 associated with porcine epidemic diarrhoea virus infection. In International journal of biological macromolecules, 250, 125962. doi:10.1016/j.ijbiomac.2023.125962. https://pubmed.ncbi.nlm.nih.gov/37499712/
3. Li, Jian J, Sarute, Nicolas, Lancaster, Eunjoo, Ross, Susan R, Scherer, Steven S. 2020. A recessive Trim2 mutation causes an axonal neuropathy in mice. In Neurobiology of disease, 140, 104845. doi:10.1016/j.nbd.2020.104845. https://pubmed.ncbi.nlm.nih.gov/32205255/
4. Wong, Nathan K P, Solly, Emma L, Le, Richard, Bursill, Christina A, Tan, Joanne T M. 2024. TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis. In International journal of molecular sciences, 25, . doi:10.3390/ijms25063343. https://pubmed.ncbi.nlm.nih.gov/38542330/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.