Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Incenpem1flox/Cya
Common Name:
Incenp-flox
Product ID:
S-CKO-18567
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Incenp-flox
Strain ID
CKOCMP-16319-Incenp-B6J-VB
Gene Name
Incenp
Product ID
S-CKO-18567
Gene Alias
2700067E22Rik; C130081E20
Background
C57BL/6JCya
NCBI ID
16319
Modification
Conditional knockout
Chromosome
19
Phenotype
MGI:1313288
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Incenpem1flox/Cya mice (Catalog S-CKO-18567) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025562
NCBI RefSeq
NM_016692
Target Region
Exon 4
Size of Effective Region
~1.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Incenp, or inner centromere protein, is crucial for correct chromosome segregation during mitosis. It is part of the chromosomal passenger complex (CPC), which plays a vital role in multiple mitotic processes. The ATM-Chk2-INCENP pathway is involved in activating the abscission checkpoint, ensuring proper cytokinesis and preventing chromosome breakage or tetraploidization [1,6].

Phosphorylation of INCENP's intrinsically disordered region affects its conformational ensemble, influencing its cohesiveness and phase behavior, which is relevant for its function in the CPC [2]. INCENP paralogs in Oikopleura dioica show distinct localizations and subfunctionalization, regulating CPC functions during embryonic divisions [3]. INCENP binds directly to tubulin, and dynamic microtubules are required for its targeting to the cleavage furrow [4]. It is also essential for proper targeting of Survivin to the centromeres and anaphase spindle [5]. INCENP-aurora B interactions modulate kinase activity and CPC localization [7], and its localization at centromeres/inner kinetochores is required for chromosome bi-orientation in budding yeast [8]. Additionally, INCENP binds the Aurora-related kinase AIRK2 and is needed to target it to chromosomes, the central spindle, and cleavage furrow [9].

In conclusion, Incenp is integral to mitotic processes such as chromosome segregation, cytokinesis, and regulation of kinase activity. Understanding Incenp's functions through model-based research, including potential KO/CKO mouse models (not explicitly detailed in provided references but generally relevant for such gene function studies), could provide insights into mitotic-related diseases and chromosomal instability.

References:
1. Petsalaki, Eleni, Zachos, George. . An ATM-Chk2-INCENP pathway activates the abscission checkpoint. In The Journal of cell biology, 220, . doi:10.1083/jcb.202008029. https://pubmed.ncbi.nlm.nih.gov/33355621/
2. Martin, Isabel M, Aponte-Santamaría, Camilo, Schmidt, Lisa, Musacchio, Andrea, Gräter, Frauke. 2021. Phosphorylation tunes elongation propensity and cohesiveness of INCENP's intrinsically disordered region. In Journal of molecular biology, 434, 167387. doi:10.1016/j.jmb.2021.167387. https://pubmed.ncbi.nlm.nih.gov/34883116/
3. Feng, Haiyang, Raasholm, Martina, Moosmann, Alexandra, Campsteijn, Coen, Thompson, Eric M. 2019. Switching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions. In Cell cycle (Georgetown, Tex.), 18, 2006-2025. doi:10.1080/15384101.2019.1634954. https://pubmed.ncbi.nlm.nih.gov/31306061/
4. Wheatley, S P, Kandels-Lewis, S E, Adams, R R, Ainsztein, A M, Earnshaw, W C. . INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow. In Experimental cell research, 262, 122-7. doi:. https://pubmed.ncbi.nlm.nih.gov/11139336/
5. Wheatley, S P, Carvalho, A, Vagnarelli, P, Earnshaw, W C. . INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. In Current biology : CB, 11, 886-90. doi:. https://pubmed.ncbi.nlm.nih.gov/11516652/
6. Petsalaki, Eleni, Zachos, George. 2021. An ATM-CHK2-INCENP pathway prevents chromatin breakage by regulating the abscission checkpoint. In Molecular & cellular oncology, 8, 1877999. doi:10.1080/23723556.2021.1877999. https://pubmed.ncbi.nlm.nih.gov/33860082/
7. Xu, Zhenjie, Ogawa, Hiromi, Vagnarelli, Paola, Earnshaw, William C, Samejima, Kumiko. . INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. In The Journal of cell biology, 187, 637-53. doi:10.1083/jcb.200906053. https://pubmed.ncbi.nlm.nih.gov/19951914/
8. García-Rodríguez, Luis J, Kasciukovic, Taciana, Denninger, Viola, Tanaka, Tomoyuki U. 2019. Aurora B-INCENP Localization at Centromeres/Inner Kinetochores Is Required for Chromosome Bi-orientation in Budding Yeast. In Current biology : CB, 29, 1536-1544.e4. doi:10.1016/j.cub.2019.03.051. https://pubmed.ncbi.nlm.nih.gov/31006569/
9. Adams, R R, Wheatley, S P, Gouldsworthy, A M, Gerloff, D L, Earnshaw, W C. . INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow. In Current biology : CB, 10, 1075-8. doi:. https://pubmed.ncbi.nlm.nih.gov/10996078/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest