C57BL/6JCya-Ideem1flox/Cya
Common Name
Ide-flox
Product ID
S-CKO-18568
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-15925-Ide-B6J-VB
When using this mouse strain in a publication, please cite “Ide-flox Mouse (Catalog S-CKO-18568) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ide-flox
Strain ID
CKOCMP-15925-Ide-B6J-VB
Gene Name
Product ID
S-CKO-18568
Gene Alias
1300012G03Rik, 4833415K22Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000131070
NCBI RefSeq
NM_031156
Target Region
Exon 3
Size of Effective Region
~0.7 kb
Overview of Gene Research
IDE, short for Insulin-degrading enzyme, is an evolutionarily conserved zinc-dependent metallopeptidase highly expressed in the brain. It is involved in cleaving multiple substrates including insulin and amyloid beta peptides, potentially linking Alzheimer's disease (AD) and type 2 diabetes (T2D) [1].
In IDE knockout (IDE-KO) mice, a specific induction of microgliosis was found in the hippocampus, influencing performance on hippocampal-dependent memory tests in 12-month-old mice. IDE absence also alters microglial responses to environmental signals, impairing the modulation of phenotypic states [1].
In addition, Klf9-/-mice showed impaired cognitive function, and Klf9 was found to stimulate IDE expression and promote Aβ degradation. Silencing IDE blocked this process, and overexpressing IDE in Klf9-/-mice ameliorated cognitive deficits and reduced Aβ content [2].
In conclusion, IDE plays a crucial role in microglial phenotypes, cognitive function, and Aβ degradation, as revealed through IDE-KO mouse models. These findings contribute to understanding the pathogenesis of Alzheimer's disease and suggest that IDE could be a potential therapeutic target for related neurodegenerative diseases [1,2].
References：
1. Corraliza-Gomez, Miriam, Bermejo, Teresa, Lilue, Jingtao, Sanchez, Diego, Ganfornina, Maria Dolores. 2023. Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging. In Journal of neuroinflammation, 20, 233. doi:10.1186/s12974-023-02914-7. https://pubmed.ncbi.nlm.nih.gov/37817156/
2. Feng, Yue-Yao, Hao, Jing-Ran, Zhang, Yu-Jie, Pan, Zhe, Chang, Yong-Sheng. 2025. Krüppel-like factor 9 alleviates Alzheimer's disease via IDE-mediated Aβ degradation. In Acta pharmacologica Sinica, , . doi:10.1038/s41401-025-01491-0. https://pubmed.ncbi.nlm.nih.gov/39962264/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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