C57BL/6JCya-Tstem1flox/Cya
Common Name
Tst-flox
Product ID
S-CKO-18607
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-22117-Tst-B6J-VB
When using this mouse strain in a publication, please cite “Tst-flox Mouse (Catalog S-CKO-18607) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tst-flox
Strain ID
CKOCMP-22117-Tst-B6J-VB
Gene Name
Product ID
S-CKO-18607
Gene Alias
rhodanese
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000058659
NCBI RefSeq
NM_009437
Target Region
Exon 2
Size of Effective Region
~1.3 kb
Overview of Gene Research
Tst, encoding toxic shock syndrome toxin-1 (TSST-1), is an important virulence factor gene in Staphylococcus aureus. TSST-1 can lead to multi-organ malfunction, and the tst gene associated Staphylococcus aureus Pathogenicity Island (SaPI) may play a critical role in the pathological process of infection. It promotes the secretion of inflammatory cytokines like IL-6, IL-2, and IL17A, which can indirectly induce immune suppression [1].
In the study of tst gene, animal experiments were carried out. BALB/c mice infected with tst gene associated SaPI positive isolates showed severe body weight loss, high bacterial load in organs such as the liver, heart, kidney, and spleen, and more severe tissue impairment compared to those infected with negative isolates [1].
In conclusion, the tst gene in Staphylococcus aureus is crucial in the pathogenesis of infections. Through animal models, it has been revealed that the tst gene associated SaPI promotes the secretion of inflammatory cytokines and induces immune suppression, highlighting its significance in understanding the mechanisms of Staphylococcus aureus-related diseases.
References：
1. Zheng, Yi, Qin, Chenhao, Zhang, Xianfeng, Zhang, Haifang, Du, Hong. 2019. The tst gene associated Staphylococcus aureus pathogenicity island facilitates its pathogenesis by promoting the secretion of inflammatory cytokines and inducing immune suppression. In Microbial pathogenesis, 138, 103797. doi:10.1016/j.micpath.2019.103797. https://pubmed.ncbi.nlm.nih.gov/31614194/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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