C57BL/6JCya-Aampem1flox/Cya
Common Name:
Aamp-flox
Product ID:
S-CKO-18670
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Aamp-flox
Strain ID
CKOCMP-227290-Aamp-B6J-VA
Gene Name
Product ID
S-CKO-18670
Gene Alias
Aamp-rs
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
1
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Aampem1flox/Cya mice (Catalog S-CKO-18670) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000178235
NCBI RefSeq
NM_001190444
Target Region
Exon 4~10
Size of Effective Region
~2.3 kb
Detailed Document
Overview of Gene Research
AAMP, also known as angio-associated migratory cell protein, is a ubiquitously expressed protein involved in multiple biological functions. It participates in cell migration and angiogenesis, and is associated with pathways like RhoA/Rho kinase signaling. AAMP is important in the context of cancer and vascular-related biological processes. Genetic models could potentially provide in-depth insights into its function [1-10].
AAMP has been identified as a binding partner of B7-H3, which may open new possibilities for targeted therapy against the pro-tumorigenic costimulatory protein B7-H3 [1]. In colorectal cancer, AAMP promotes metastasis by suppressing SMURF2-mediated ubiquitination and degradation of RhoA [2]. It also regulates endothelial cell migration and angiogenesis through RhoA/Rho kinase signaling, and knockdown of AAMP impairs VEGF-induced endothelial cell tube formation and aortic ring angiogenic sprouting [3]. In non-small cell lung cancer, AAMP interacts with CDC42 and enhances cell migration and invasion [4].
In conclusion, AAMP plays crucial roles in cell migration, angiogenesis, and cancer-related processes. Findings from various studies suggest its potential as a therapeutic target in cancer and for angiogenesis-related diseases. Understanding AAMP function through genetic models can contribute to better insights into these biological functions and disease mechanisms.
References：
1. Ciprut, Sara, Berberich, Anne, Knoll, Maximilian, Wick, Wolfgang, Lemke, Dieter. 2022. AAMP is a binding partner of costimulatory human B7-H3. In Neuro-oncology advances, 4, vdac098. doi:10.1093/noajnl/vdac098. https://pubmed.ncbi.nlm.nih.gov/35919070/
2. Wu, Yuhui, Liu, Bofang, Lin, Weiqiang, Han, Weidong, Xie, Jiansheng. 2021. AAMP promotes colorectal cancermetastasis by suppressing SMURF2-mediatedubiquitination and degradation of RhoA. In Molecular therapy oncolytics, 23, 515-530. doi:10.1016/j.omto.2021.11.007. https://pubmed.ncbi.nlm.nih.gov/34901393/
3. Hu, Jianjun, Qiu, Juhui, Zheng, Yiming, Xie, Xiang, Wang, Guixue. 2015. AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling. In Annals of biomedical engineering, 44, 1462-74. doi:10.1007/s10439-015-1442-0. https://pubmed.ncbi.nlm.nih.gov/26350504/
4. Yao, Shun, Shi, Feifei, Mu, Ning, Liu, Xiangguo, Su, Ling. 2020. Angio-associated migratory cell protein (AAMP) interacts with cell division cycle 42 (CDC42) and enhances migration and invasion in human non-small cell lung cancer cells. In Cancer letters, 502, 1-8. doi:10.1016/j.canlet.2020.11.050. https://pubmed.ncbi.nlm.nih.gov/33279622/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen