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C57BL/6JCya-Osbp2em1flox/Cya
Common Name:
Osbp2-flox
Product ID:
S-CKO-18696
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Osbp2-flox
Strain ID
CKOCMP-74309-Osbp2-B6J-VC
Gene Name
Osbp2
Product ID
S-CKO-18696
Gene Alias
1700095P05Rik; C630001G20Rik; Gm244; ORP-4; OSBPL1
Background
C57BL/6JCya
NCBI ID
74309
Modification
Conditional knockout
Chromosome
11
Phenotype
MGI:1921559
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Osbp2em1flox/Cya mice (Catalog S-CKO-18696) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000070552
NCBI RefSeq
NM_152818
Target Region
Exon 6~8
Size of Effective Region
~1.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Osbp2, also known as HLM, is a member of the oxysterol-binding protein (OSBP) family. It binds specifically to oxysterols, like 7-ketocholesterol, and is involved in processes such as lipid trafficking and metabolism [4]. It has been detected mainly in retina, testis, and fetal liver, and is associated with membranes [4].

In various diseases, Osbp2 shows significant associations. In hepatocellular carcinoma (HCC), it is related to prognosis, immunotherapy, and chemotherapy resistance. A Cox model including Osbp2 suggested unfavorable overall survival in the high-risk score group, and Osbp2 could inhibit NK and TIL cell infiltration, impair IFN responses, and contribute to chemotherapy resistance [1]. In pancreatic ductal adenocarcinoma (PDAC), overexpression of Osbp2 promoted cell migration, invasion, proliferation, and chemotherapy resistance, and decreased apoptosis through epithelial-mesenchymal transition [3]. In chronic myeloid leukemia, it was expressed in 80% of analyzed patients, potentially involved in maintaining the undifferentiated state for leukemogenesis [2]. It may also play roles in age-related macular degeneration, opisthorchiasis-associated cholangiocarcinoma, and is related to susceptibility and resistance of Pekin ducks to DHAV-3, as well as in the reproduction of Kashmir cattle [5,6,7,8]. In primary immune thrombocytopenia (ITP), its expression was lower compared to normal subjects, and it was negatively correlated with macrophage M1 polarization [9]. In bovine testes, the target gene Osbp2 was associated with sexual maturation [10].

In conclusion, Osbp2 has diverse functions related to lipid-associated processes and is significantly involved in multiple disease conditions including HCC, PDAC, leukemia, and ITP. Its role in these diseases provides potential directions for further research on disease mechanisms and therapeutic strategies.

References:
1. Wu, Qinjuan, Li, Xin, Long, Menghong, Xie, Xianfeng, Liu, Qing. 2023. Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma. In Scientific reports, 13, 18642. doi:10.1038/s41598-023-46057-4. https://pubmed.ncbi.nlm.nih.gov/37903971/
2. Henriques Silva, Nathalie, Vasconcellos Fournier, Marcia, Pimenta, Glicinia, Spector, Nelson, da Costa Carvalho, Maria da Gloria. . HLM/OSBP2 is expressed in chronic myeloid leukemia. In International journal of molecular medicine, 12, 663-6. doi:. https://pubmed.ncbi.nlm.nih.gov/12964051/
3. Huang, Shuai, Zhang, Xudong, Luo, Kai, Jiang, Jianhua, Li, Renfeng. 2022. Oxysterol-Binding Protein 2 Promotes Pancreatic Ductal Adenocarcinoma Progression Through Epithelial-Mesenchymal Transition. In Frontiers in oncology, 11, 762233. doi:10.3389/fonc.2021.762233. https://pubmed.ncbi.nlm.nih.gov/35127474/
4. Moreira, E F, Jaworski, C, Li, A, Rodriguez, I R. 2001. Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina. In The Journal of biological chemistry, 276, 18570-8. doi:. https://pubmed.ncbi.nlm.nih.gov/11278871/
5. Wang, Xia, Ding, Dingbang, Liu, Ying, Hou, Shuisheng, Zhang, Yunsheng. 2023. Plasma lipidome reveals susceptibility and resistance of Pekin ducks to DHAV-3. In International journal of biological macromolecules, 253, 127095. doi:10.1016/j.ijbiomac.2023.127095. https://pubmed.ncbi.nlm.nih.gov/37758112/
6. Ahmed, Zulfiqar, Xiang, Weixuan, Wang, Fuwen, Lei, Chuzhao, Xu, Dequan. 2024. Whole-genome resequencing deciphers patterns of genetic diversity, phylogeny, and evolutionary dynamics in Kashmir cattle. In Animal genetics, 55, 511-526. doi:10.1111/age.13434. https://pubmed.ncbi.nlm.nih.gov/38726735/
7. Torrini, Margherita, Marchese, Cristiana, Vanzetti, Mario, Garré, Cecilia, Mareni, Cristina. . Mutation analysis of oxisterol-binding-protein gene in patients with age-related macular degeneration. In Genetic testing, 11, 421-6. doi:10.1089/gte.2007.0021. https://pubmed.ncbi.nlm.nih.gov/18294060/
8. Loilome, Watcharin, Wechagama, Pairoj, Namwat, Nisana, Kuver, Rahul, Yongvanit, Puangrat. 2011. Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis. In Parasitology international, 61, 136-9. doi:10.1016/j.parint.2011.07.003. https://pubmed.ncbi.nlm.nih.gov/21763455/
9. Wang, Ming-Jing, Song, Ying, Guo, Xiao-Qing, Xu, Yong-Gang, Hu, Xiao-Mei. 2022. The Construction of ITP Diagnostic Modeling Based on the Expressions of Hub Genes Associated with M1 Polarization of Macrophages. In Journal of inflammation research, 15, 5905-5915. doi:10.2147/JIR.S364414. https://pubmed.ncbi.nlm.nih.gov/36274827/
10. Gao, Yuan, Li, Shipeng, Lai, Zhenyu, Chen, Hong, Dang, Ruihua. 2019. Analysis of Long Non-Coding RNA and mRNA Expression Profiling in Immature and Mature Bovine (Bos taurus) Testes. In Frontiers in genetics, 10, 646. doi:10.3389/fgene.2019.00646. https://pubmed.ncbi.nlm.nih.gov/31333723/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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