C57BL/6JCya-Fndc3bem1flox/Cya
Common Name
Fndc3b-flox
Product ID
S-CKO-18704
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-72007-Fndc3b-B6J-VB
When using this mouse strain in a publication, please cite “Fndc3b-flox Mouse (Catalog S-CKO-18704) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Fndc3b-flox
Strain ID
CKOCMP-72007-Fndc3b-B6J-VB
Gene Name
Product ID
S-CKO-18704
Gene Alias
1600019O04Rik, Fad104, mKIAA4164
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000195008
NCBI RefSeq
NM_001356953
Target Region
Exon 4
Size of Effective Region
~0.9 kb
Overview of Gene Research
Fncd3b, or fibronectin type III domain-containing protein 3B, is an important regulator of metabolism. It has been associated with multiple biological pathways such as the AMP-activated protein kinase (AMPK) pathway, endoplasmic reticulum (ER) stress, the unfolded protein response (UPR), and the Wnt/β-catenin signaling pathway. Its dysregulation is linked to various diseases, highlighting its biological importance. Genetic models, especially knockout mouse models, are valuable for studying its functions [1,2,3].
In a study on alcoholic liver disease (ALD), hepatocyte-specific Fndc3b knockdown in C57BL/6 N mice showed that Fndc3b deletion aggravated alcohol-induced liver steatosis via AMPK inhibition and exacerbated ethanol-mediated lipid peroxidation. The study also revealed a connection between Fndc3b and ferroptosis, indicating that Fndc3b plays a critical role in preventing hepatic steatosis and ferroptosis in response to chronic alcohol consumption [1].
In conclusion, Fndc3b is involved in regulating metabolism-related biological processes. Its functions in preventing hepatic steatosis and ferroptosis in ALD, as revealed by gene-knockout mouse models, highlight its potential as a therapeutic target for this disease. Additionally, its association with multiple cancer-related processes in various cancers implies its significance in oncology research [1].
References：
1. You, Yajing, Liu, Chenxi, Liu, Tiantian, Qi, Jianni, Zhu, Qiang. 2022. FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease. In Free radical biology & medicine, 193, 808-819. doi:10.1016/j.freeradbiomed.2022.10.322. https://pubmed.ncbi.nlm.nih.gov/36336231/
2. Han, Bing, Wang, Hongbo, Zhang, Jianzhao, Tian, Jingwei. 2019. FNDC3B is associated with ER stress and poor prognosis in cervical cancer. In Oncology letters, 19, 406-414. doi:10.3892/ol.2019.11098. https://pubmed.ncbi.nlm.nih.gov/31897153/
3. Li, Ying-Qing, Chen, Yang, Xu, Ya-Fei, Tang, Ling-Long, Liu, Na. 2020. FNDC3B 3'-UTR shortening escapes from microRNA-mediated gene repression and promotes nasopharyngeal carcinoma progression. In Cancer science, 111, 1991-2003. doi:10.1111/cas.14394. https://pubmed.ncbi.nlm.nih.gov/32232887/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.