C57BL/6JCya-Fndc3bem1flox/Cya
Common Name:
Fndc3b-flox
Product ID:
S-CKO-18704
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fndc3b-flox
Strain ID
CKOCMP-72007-Fndc3b-B6J-VB
Gene Name
Product ID
S-CKO-18704
Gene Alias
1600019O04Rik; Fad104; mKIAA4164
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fndc3bem1flox/Cya mice (Catalog S-CKO-18704) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000195008
NCBI RefSeq
NM_001356953
Target Region
Exon 4
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Fncd3b, or fibronectin type III domain-containing protein 3B, is an important regulator of metabolism. It has been associated with multiple biological pathways such as the AMP-activated protein kinase (AMPK) pathway, endoplasmic reticulum (ER) stress, the unfolded protein response (UPR), and the Wnt/β-catenin signaling pathway. Its dysregulation is linked to various diseases, highlighting its biological importance. Genetic models, especially knockout mouse models, are valuable for studying its functions [1,2,3].
In a study on alcoholic liver disease (ALD), hepatocyte-specific Fndc3b knockdown in C57BL/6 N mice showed that Fndc3b deletion aggravated alcohol-induced liver steatosis via AMPK inhibition and exacerbated ethanol-mediated lipid peroxidation. The study also revealed a connection between Fndc3b and ferroptosis, indicating that Fndc3b plays a critical role in preventing hepatic steatosis and ferroptosis in response to chronic alcohol consumption [1].
In conclusion, Fndc3b is involved in regulating metabolism-related biological processes. Its functions in preventing hepatic steatosis and ferroptosis in ALD, as revealed by gene-knockout mouse models, highlight its potential as a therapeutic target for this disease. Additionally, its association with multiple cancer-related processes in various cancers implies its significance in oncology research [1].
References:
1. You, Yajing, Liu, Chenxi, Liu, Tiantian, Qi, Jianni, Zhu, Qiang. 2022. FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease. In Free radical biology & medicine, 193, 808-819. doi:10.1016/j.freeradbiomed.2022.10.322. https://pubmed.ncbi.nlm.nih.gov/36336231/
2. Han, Bing, Wang, Hongbo, Zhang, Jianzhao, Tian, Jingwei. 2019. FNDC3B is associated with ER stress and poor prognosis in cervical cancer. In Oncology letters, 19, 406-414. doi:10.3892/ol.2019.11098. https://pubmed.ncbi.nlm.nih.gov/31897153/
3. Li, Ying-Qing, Chen, Yang, Xu, Ya-Fei, Tang, Ling-Long, Liu, Na. 2020. FNDC3B 3'-UTR shortening escapes from microRNA-mediated gene repression and promotes nasopharyngeal carcinoma progression. In Cancer science, 111, 1991-2003. doi:10.1111/cas.14394. https://pubmed.ncbi.nlm.nih.gov/32232887/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen