C57BL/6JCya-Fosbem1flox/Cya
Common Name:
Fosb-flox
Product ID:
S-CKO-18762
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Fosb-flox
Strain ID
CKOCMP-14282-Fosb-B6J-VB
Gene Name
Product ID
S-CKO-18762
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fosbem1flox/Cya mice (Catalog S-CKO-18762) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000003640
NCBI RefSeq
NM_008036
Target Region
Exon 2~3
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
Fosb, also known as FBJ Murine Osteosarcoma Viral Oncogene Homolog B, is a proto-oncogene and a member of the Fos family of transcription factors. It plays a role in a wide variety of tumourigenic processes and is involved in regulating gene expression. ΔFosB, a product of the FosB gene, accumulates in response to repeated stimulation due to its unusual protein stability, and is associated with pathways related to stress, reward, and neuronal excitability [2].
In mouse models, persistent ΔFosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice, acting through discrete modes of hippocampal target gene regulation to modulate neuronal excitability [1]. In mast cell-specific FosB knockout male mice, FOSB/ΔFOSB modulates mast cell functions by limiting reactivity to allergen-like stimuli both in vitro and in vivo, mediated in part by enhanced DUSP4 expression which attenuates MAPK signaling [3].
In conclusion, Fosb and its product ΔFosB are important regulators in multiple biological processes. Mouse knockout models have revealed their role in diseases such as epilepsy and in modulating allergic inflammation, contributing to our understanding of these disease mechanisms and potentially guiding future therapeutic developments.
References:
1. Stephens, Gabriel S, Park, Jin, Eagle, Andrew, Robison, A J, Chin, Jeannie. 2024. Persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice. In Progress in neurobiology, 237, 102612. doi:10.1016/j.pneurobio.2024.102612. https://pubmed.ncbi.nlm.nih.gov/38642602/
2. Nestler, Eric J. 2014. ∆FosB: a transcriptional regulator of stress and antidepressant responses. In European journal of pharmacology, 753, 66-72. doi:10.1016/j.ejphar.2014.10.034. https://pubmed.ncbi.nlm.nih.gov/25446562/
3. Duque-Wilckens, Natalia, Joseph, Dimitri, Syed, Meesum, Moesers, Adam J, Robison, A J. 2025. FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male mice. In bioRxiv : the preprint server for biology, , . doi:10.1101/2024.05.06.592755. https://pubmed.ncbi.nlm.nih.gov/38766119/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen