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C57BL/6NCya-Adam10em1flox/Cya
Common Name:
Adam10-flox
Product ID:
S-CKO-18794
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Adam10-flox
Strain ID
CKOCMP-11487-Adam10-B6N-VA
Gene Name
Adam10
Product ID
S-CKO-18794
Gene Alias
1700031C13Rik; MADM; kuz; kuzbanian
Background
C57BL/6NCya
NCBI ID
11487
Modification
Conditional knockout
Chromosome
9
Phenotype
MGI:109548
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Adam10em1flox/Cya mice (Catalog S-CKO-18794) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000067880
NCBI RefSeq
NM_007399
Target Region
Exon 7~8
Size of Effective Region
~3.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
ADAM10, a member of the ADAM superfamily, is a membrane-bound protein with a catalytic domain on the cell surface. It functions as a sheddase, cleaving over 100 anchored cell-surface proteins, and is involved in diverse cellular processes such as cell adhesion, migration, and proteolysis. ADAM10 is best known for its role in the Notch signaling pathway. It is expressed in most tissues of the body and is crucial for mammalian development, physiology, and non-amyloidogenic cleavage of APP as the primary α-secretase [1,2,3].

In hair follicles, ablation of the ADAM10-Notch signaling axis in mouse models impaired the innate epithelial barrier, led to skin dysbiosis, and ultimately caused hair follicle destruction due to inflammation [4]. In the context of cancer, ADAM10 cleavage of Trop-2 was shown to act as an activator switch for cancer growth and metastasis, and ADAM10 also modulates the efficacy of T-cell-mediated therapy in solid tumors [5,6]. In Alzheimer's disease, lower levels of ADAM10 were found in platelets of AD patients, while higher levels were seen in plasma, and CSF results were controversial, indicating its potential as a biomarker [7].

In conclusion, ADAM10 is a multifunctional protein involved in various biological processes and diseases. Studies using mouse models have revealed its role in maintaining tissue integrity, such as in hair follicles, and its implications in cancer progression and Alzheimer's disease, highlighting its potential as a therapeutic target and biomarker in these disease areas.

References:
1. Shahid, Shifa, Ikeda, Atsushi, Layana, Michelle C, Bartlett, John D. 2022. ADAM10: Possible functions in enamel development. In Frontiers in physiology, 13, 1032383. doi:10.3389/fphys.2022.1032383. https://pubmed.ncbi.nlm.nih.gov/36505044/
2. Lipper, Colin H, Egan, Emily D, Gabriel, Khal-Hentz, Blacklow, Stephen C. 2023. Structural basis for membrane-proximal proteolysis of substrates by ADAM10. In Cell, 186, 3632-3641.e10. doi:10.1016/j.cell.2023.06.026. https://pubmed.ncbi.nlm.nih.gov/37516108/
3. Dorta, Sabrina, Alexandre-Silva, Vanessa, Popolin, Cecilia Patricia, Endres, Kristina, Cominetti, Marcia Regina. 2024. ADAM10 isoforms: Optimizing usage of antibodies based on protein regulation, structural features, biological activity and clinical relevance to Alzheimer's disease. In Ageing research reviews, 101, 102464. doi:10.1016/j.arr.2024.102464. https://pubmed.ncbi.nlm.nih.gov/39173916/
4. Sakamoto, Keiko, Jin, Seon-Pil, Goel, Shubham, Kong, Heidi H, Nagao, Keisuke. 2021. Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction. In Immunity, 54, 2321-2337.e10. doi:10.1016/j.immuni.2021.09.001. https://pubmed.ncbi.nlm.nih.gov/34582748/
5. Trerotola, Marco, Guerra, Emanuela, Ali, Zeeshan, Lattanzio, Rossano, Alberti, Saverio. 2021. Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis. In Neoplasia (New York, N.Y.), 23, 415-428. doi:10.1016/j.neo.2021.03.006. https://pubmed.ncbi.nlm.nih.gov/33839455/
6. Abdalla, Ahmed Me, Miao, Yu, Ming, Ning, Ouyang, Chenxi. 2024. ADAM10 modulates the efficacy of T-cell-mediated therapy in solid tumors. In Immunology and cell biology, 102, 907-923. doi:10.1111/imcb.12826. https://pubmed.ncbi.nlm.nih.gov/39417304/
7. Oliveira Monteiro E Pereira de Almeida, M P, Valle Pedroso, R, Mantellatto Grigoli, M, Manzine, P R, Cominetti, M R. 2023. ADAM10 as a biomarker for Alzheimer's disease: A systematic review. In Revue neurologique, 180, 1-11. doi:10.1016/j.neurol.2023.04.002. https://pubmed.ncbi.nlm.nih.gov/37460331/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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