C57BL/6JCya-Krt79em1flox/Cya
Common Name:
Krt79-flox
Product ID:
S-CKO-18911
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Krt79-flox
Strain ID
CKOCMP-223917-Krt79-B6J-VB
Gene Name
Product ID
S-CKO-18911
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Krt79em1flox/Cya mice (Catalog S-CKO-18911) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023799
NCBI RefSeq
NM_146063
Target Region
Exon 3~4
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Krt79, a type II cytokeratin, is a key structural protein. It has been identified as a regulator of hair canal morphogenesis and regeneration in the skin [1]. In the liver, it is a PPARA target, and its expression is highly associated with liver damage, suggesting it could be a diagnostic marker for human liver diseases [1].
In mouse studies, Krt79 expression is undetectable in normal mice but significantly increased by PPARA agonists like WY-14643 and fenofibrate, and completely abolished in Ppara-null mice, indicating PPARA's control over Krt79 [1]. In cashmere goats, multi-omics analysis shows Krt79 has a positive regulatory effect on cashmere fineness [2]. During mammalian skin development, K79+ cells (expressing Krt79) at the distal tips of columns in early hair buds change shape, recede, and undergo cell death to create an orifice for hair emergence, and defects in this process may lead to hair-related pathologies [3].
In conclusion, Krt79 is involved in multiple biological processes, such as hair canal formation in skin development and potentially in liver disease development. Mouse models, especially those with Ppara-null background, have been crucial in revealing its role in the liver. Its role in cashmere fineness regulation also provides new insights into animal fiber development. These findings contribute to our understanding of related biological processes and potential disease mechanisms.
References:
1. Kim, Donghwan, Choi, Inwook, Ha, Sang Keun, Gonzalez, Frank J. 2023. Keratin 79 is a PPARA target that is highly expressed by liver damage. In Biochemical and biophysical research communications, 650, 132-136. doi:10.1016/j.bbrc.2023.01.071. https://pubmed.ncbi.nlm.nih.gov/36796223/
2. Xu, Yanan, Zhang, Yu, Qin, Yuting, Li, Shuaitong, Wang, Zeying. 2023. Multi-omics analysis of functional substances and expression verification in cashmere fineness. In BMC genomics, 24, 720. doi:10.1186/s12864-023-09825-0. https://pubmed.ncbi.nlm.nih.gov/38017403/
3. Mesler, Arlee L, Benedeck, Rachel E, Wong, Sunny Y. 2020. Preparing the hair follicle canal for hair shaft emergence. In Experimental dermatology, 30, 472-478. doi:10.1111/exd.14210. https://pubmed.ncbi.nlm.nih.gov/33025661/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen