C57BL/6JCya-Hbb-bh2em1flox/Cya
Common Name:
Hbb-bh2-flox
Product ID:
S-CKO-18970
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Hbb-bh2-flox
Strain ID
CKOCMP-436003-Hbb-bh2-B6J-VB
Gene Name
Product ID
S-CKO-18970
Gene Alias
EG436003; Gm5736
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Hbb-bh2em1flox/Cya mice (Catalog S-CKO-18970) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000106866
NCBI RefSeq
NM_001127686
Target Region
Exon 1~3
Size of Effective Region
~2.8 kb
Detailed Document
Overview of Gene Research
Hbb-bh2 is a gene within the beta-globin complex. The beta-globin complex is crucial for oxygen transport as its gene products form part of hemoglobin. Understanding Hbb-bh2 can provide insights into normal oxygen-carrying mechanisms and related physiological processes. Genetic models, like mouse models, are valuable for studying Hbb-bh2's function [1].
Comparisons of the beta-globin complex between the deer mouse (Peromyscus maniculatus) and the laboratory mouse (Mus domesticus) show organizational trends. The adult region in Peromyscus has diverged from that in Mus, and there may have been a loss of the Hbb-bh2 pseudogene in Peromyscus. This suggests that changes in the Hbb-bh2 gene region can occur during evolution, potentially affecting the function of the beta-globin complex [1].
In conclusion, Hbb-bh2 is an important part of the beta-globin complex. Through research on mouse models, we can see that evolutionary changes in the Hbb-bh2 region may impact the function of the beta-globin complex, which is vital for oxygen transport. Understanding Hbb-bh2 helps in comprehending normal physiological processes related to oxygen-carrying capacity and the evolution of the beta-globin complex.
References：
1. Padgett, R W, Loeb, D D, Snyder, L R, Edgell, M H, Hutchison, C A. . The molecular organization of the beta-globin complex of the deer mouse, Peromyscus maniculatus. In Molecular biology and evolution, 4, 30-45. doi:. https://pubmed.ncbi.nlm.nih.gov/3447002/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen