C57BL/6JCya-Mrpl13em1flox/Cya
Common Name:
Mrpl13-flox
Product ID:
S-CKO-18989
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Mrpl13-flox
Strain ID
CKOCMP-68537-Mrpl13-B6J-VB
Gene Name
Product ID
S-CKO-18989
Gene Alias
1110002D09Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mrpl13em1flox/Cya mice (Catalog S-CKO-18989) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000172387
NCBI RefSeq
NM_026759
Target Region
Exon 3
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Mrpl13, a mitochondrial ribosomal protein, is an essential component for the structural and functional integrity of the mitoribosome complex, responsible for synthesizing mitochondrial proteins in cells [5,7]. It may be involved in pathways like cell cycle, p53 signaling, PI3K/AKT/mTOR signaling, and Notch signaling pathway, and is of great biological importance in cellular and organismal viability [4,6,7].
In breast cancer, high Mrpl13 expression is associated with worse overall survival, metastasis, and cell invasion, and knockdown of Mrpl13 restrains cell proliferation, migration, and the EMT process through inhibiting the PI3K/AKT/mTOR signaling pathway [1,2,4]. In non-small cell lung cancer, high Mrpl13 level is correlated with poor T classification and overall survival, and its knockdown inhibits cell proliferation [3]. In gastric cancer, high Mrpl13 expression promotes cell cycle progression and proliferation by inhibiting p53 signaling, affecting long-term prognosis [6].
In conclusion, Mrpl13 plays a significant role in promoting cancer cell proliferation, migration, and cell cycle progression in multiple cancer types, including breast, non-small cell lung, and gastric cancers. Studies on Mrpl13 knockout or knockdown in cancer cell models have revealed its importance in cancer-related biological processes, suggesting it could be a potential biomarker and therapeutic target for these diseases.
References:
1. Dai, Pei, Chen, Yan'an, Zhang, Xiao, Liu, Long, Cheng, Zhenbo. 2024. MRPL13 is a metastatic and prognostic marker of breast cancer: A silico analysis accompanied with experimental validation. In Gene, 932, 148908. doi:10.1016/j.gene.2024.148908. https://pubmed.ncbi.nlm.nih.gov/39218414/
2. Tao, Zuo, Suo, Huandan, Zhang, Lei, Zhao, Yujie, Chen, Bo. 2020. MRPL13 is a Prognostic Cancer Biomarker and Correlates with Immune Infiltrates in Breast Cancer. In OncoTargets and therapy, 13, 12255-12268. doi:10.2147/OTT.S263998. https://pubmed.ncbi.nlm.nih.gov/33273831/
3. Jing, Chuanqing, Fu, Rong, Wang, Can, Li, Xiurong, Zhang, Wei. 2021. MRPL13 Act as a Novel Therapeutic Target and Could Promote Cell Proliferation in Non-Small Cell Lung Cancer. In Cancer management and research, 13, 5535-5545. doi:10.2147/CMAR.S316428. https://pubmed.ncbi.nlm.nih.gov/34285575/
4. Cai, Miaomiao, Li, Hanning, Chen, Runfa, Zhou, Xiang. 2021. MRPL13 Promotes Tumor Cell Proliferation, Migration and EMT Process in Breast Cancer Through the PI3K-AKT-mTOR Pathway. In Cancer management and research, 13, 2009-2024. doi:10.2147/CMAR.S296038. https://pubmed.ncbi.nlm.nih.gov/33658859/
5. Cheong, Agnes, Lingutla, Ranjana, Mager, Jesse. 2020. Expression analysis of mammalian mitochondrial ribosomal protein genes. In Gene expression patterns : GEP, 38, 119147. doi:10.1016/j.gep.2020.119147. https://pubmed.ncbi.nlm.nih.gov/32987154/
6. Wang, L, Xia, Y, Zhang, Z, Song, X, Zuo, L. . [High expression of MRPL13 promotes cell cycle progression and proliferation of gastric cancer cells by inhibiting p53 signaling to affect long-term prognosis]. In Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 43, 1558-1566. doi:10.12122/j.issn.1673-4254.2023.09.13. https://pubmed.ncbi.nlm.nih.gov/37814870/
7. Zhong, Xugang, He, Zeju, Fan, Yong, Bi, Qing, Zhu, Senbo. 2023. Multi-omics analysis of MRPL-13 as a tumor-promoting marker from pan-cancer to lung adenocarcinoma. In Aging, 15, 10640-10680. doi:10.18632/aging.205104. https://pubmed.ncbi.nlm.nih.gov/37827692/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen