TASOR2 is a paralog of TASOR, and it is the core of the HUSH2 complex. The HUSH2 complex is involved in regulating the immune response to retroelement invasion and retrotransposon silencing. It is recruited by the transcription factor IRF2 to repress interferon-stimulated genes, thus playing a role in the epigenetic and immune aspects of genome defense [1].

Two studies identified the HUSH2 complex centered around TASOR2. They found that HUSH and HUSH2 localize to distinct genomic loci. HUSH2 targets and represses KRAB-ZNFs and interferon signaling and response genes. In silico protein structure predictions and amino-acid substitution experiments were used to study the importance of HUSH complex quantities in regulating LINE-1 activity. Dynamic changes in TASOR and TASOR2 expression enable cells to finely tune HUSH-mediated silencing [2,3].

In conclusion, TASOR2, as the core of the HUSH2 complex, is crucial for the regulation of the immune response to retroelement invasion and retrotransposon silencing. Studies on TASOR2 using in silico predictions and construct-based experiments help to understand the interplay between HUSH complexes, which may provide insights into the mechanisms of related diseases and potential treatment strategies.