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C57BL/6JCya-Fubp3em1flox/Cya
Common Name:
Fubp3-flox
Product ID:
S-CKO-19015
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Fubp3-flox
Strain ID
CKOCMP-320267-Fubp3-B6J-VB
Gene Name
Fubp3
Product ID
S-CKO-19015
Gene Alias
A330051M14Rik; FBP3; Marta2
Background
C57BL/6JCya
NCBI ID
320267
Modification
Conditional knockout
Chromosome
2
Phenotype
MGI:2443699
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fubp3em1flox/Cya mice (Catalog S-CKO-19015) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000055244
NCBI RefSeq
NM_001033389
Target Region
Exon 4~7
Size of Effective Region
~4.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
FUBP3, also known as far upstream element-binding protein 3, is a transcription factor that plays crucial roles in multiple biological processes. It is involved in various pathways, such as those related to immune responses, cell proliferation, and viral replication [1,2,4,5,6,7]. Its functions are of great biological importance as it impacts diseases like Alzheimer's disease, chronic myeloid leukaemia, neuroblastoma, and more [1,2,3]. Genetic models, like gene knockout (KO) or conditional knockout (CKO) mouse models, would be valuable for in-depth functional studies of FUBP3.

In Alzheimer's disease, FUBP3 was found to mediate amyloid-β-induced neuronal NLRP3 expression. In aged wild-type and Alzheimer's disease mouse models, FUBP3 expression increased in cortical neurons. FUBP3 was required for endogenous NLRP3 expression and tau phosphorylation in the presence of amyloid-β, suggesting its role in the transition from amyloid-β deposition to tau phosphorylation [1].

In chronic myeloid leukaemia, microdeletions of the FUBP3 gene and its reduced expression were associated with poor prognostic markers. In K562 cells, decreased FUBP3 protein was linked to increased cell proliferation and survival via MAPK-ERK pathway activation [2].

In neuroblastoma, GATA2-AS1 bound with FUBP3 to repress its liquid-liquid phase separation and interaction with SUZ12, inhibiting the malate-aspartate shuttle and neuroblastoma progression [3].

For porcine epidemic diarrhea virus (PEDV), FUBP3 could suppress PEDV replication by degrading the viral nucleocapsid protein and inducing type-I interferon production [4].

In Japanese encephalitis virus (JEV) infection, knockdown of FUBP3 decreased JEV viral titer, while overexpression increased viral infectivity, indicating FUBP3's role in regulating JEV RNA replication [5].

Lnc-EST12 interacted with FUBP3 in mouse macrophages, suppressing anti-mycobacterial innate immunity [6].

In glioblastoma, FUBP3 was identified as a key candidate gene associated with immune surveillance and GBM development [7].

In clear cell renal cell carcinoma, FUBP1 and FUBP3 activated the expression of USP7, which promoted tumor progression by stabilizing HIF2α [8].

In conclusion, FUBP3 has diverse essential biological functions, regulating immune responses, cell proliferation, and viral replication. Studies using KO/CKO mouse models and other functional experiments have revealed its significance in multiple disease areas, including Alzheimer's disease, leukaemia, neuroblastoma, and viral-related diseases. Understanding FUBP3 provides insights into disease mechanisms and potential therapeutic targets.

References:
1. Yao, Jing, Li, Yuan, Liu, Xi, Wang, Zhe, Song, Weihong. 2024. FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression. In Neural regeneration research, 20, 2068-2083. doi:10.4103/NRR.NRR-D-23-01799. https://pubmed.ncbi.nlm.nih.gov/39254567/
2. Sharma, Mugdha, Anandram, Seetharam, Ross, Cecil, Srivastava, Sweta. 2022. FUBP3 regulates chronic myeloid leukaemia progression through PRC2 complex regulated PAK1-ERK signalling. In Journal of cellular and molecular medicine, 27, 15-29. doi:10.1111/jcmm.17584. https://pubmed.ncbi.nlm.nih.gov/36478132/
3. Wang, Xiaojing, Guo, Yanhua, Chen, Guo, Zheng, Liduan, Tong, Qiangsong. 2023. Therapeutic targeting of FUBP3 phase separation by GATA2-AS1 inhibits malate-aspartate shuttle and neuroblastoma progression via modulating SUZ12 activity. In Oncogene, 42, 2673-2687. doi:10.1038/s41388-023-02798-0. https://pubmed.ncbi.nlm.nih.gov/37537343/
4. Dong, Sujie, Kong, Ning, Wang, Chunmei, Tong, Guangzhi, Shan, Tongling. 2022. FUBP3 Degrades the Porcine Epidemic Diarrhea Virus Nucleocapsid Protein and Induces the Production of Type I Interferon. In Journal of virology, 96, e0061822. doi:10.1128/jvi.00618-22. https://pubmed.ncbi.nlm.nih.gov/35695513/
5. Xu, Peng, Tong, Wei, Chen, Young-Mao. 2021. FUSE binding protein FUBP3 is a potent regulator in Japanese encephalitis virus infection. In Virology journal, 18, 224. doi:10.1186/s12985-021-01697-8. https://pubmed.ncbi.nlm.nih.gov/34794468/
6. Yao, Qili, Xie, Yan, Xu, Dandan, Xiong, Huan, Zhang, Xiao-Lian. 2022. Lnc-EST12, which is negatively regulated by mycobacterial EST12, suppresses antimycobacterial innate immunity through its interaction with FUBP3. In Cellular & molecular immunology, 19, 883-897. doi:10.1038/s41423-022-00878-x. https://pubmed.ncbi.nlm.nih.gov/35637281/
7. Li, Jianmin, Zhang, Zhao, Guo, Ke, Zhang, Xinfan, Wang, Zi. 2022. Identification of a key glioblastoma candidate gene, FUBP3, based on weighted gene co-expression network analysis. In BMC neurology, 22, 139. doi:10.1186/s12883-022-02661-x. https://pubmed.ncbi.nlm.nih.gov/35413821/
8. Tu, Rongfu, Ma, Junpeng, Chen, Yule, Lu, Xinlan, Zhang, Chengsheng. 2024. USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression. In Cell death & disease, 15, 749. doi:10.1038/s41419-024-07136-0. https://pubmed.ncbi.nlm.nih.gov/39406703/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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