NRBP1, or nuclear receptor-binding protein 1, is an adaptor protein with multiple domains. It is involved in various biological functions, such as regulating cell growth, synaptic maintenance, and signal transduction pathways. It participates in pathways like the ERK-NRBP1-CREB-BDNF signaling pathway in microglia, the PI3K/Akt signaling pathway, and the Wnt/β-catenin pathway, and impacts important physiological processes in different cell types and tissues [1,2,3].

In a chronic social defeat stress (CSDS) mouse model, (R)-ketamine increased NRBP1 expression in microglia of the mouse medial prefrontal cortex, and microglial depletion or inhibition blocked the antidepressant-like effects of (R)-ketamine, suggesting NRBP1's role in (R)-ketamine-mediated antidepressant actions through the ERK-NRBP1-CREB-BDNF pathway [1]. In glioblastoma cells, knockout of NRBP1 suppressed cell proliferation, invasion, and migration, and in a mouse model, NRBP1 knockdown led to decreased tumor growth, indicating its role in promoting glioblastoma malignancy via the PI3K/Akt pathway [2]. In HK-2 cells, knockdown of NRBP1 increased the expression of the uric acid transporter ABCG2 by activating the Wnt/β-catenin pathway, suggesting its potential role in attenuating hyperuricemia and gout [3].

In conclusion, NRBP1 is crucial in multiple biological processes and disease conditions. Model-based research, especially gene knockout in mouse models, has revealed its significance in areas such as antidepressant action, glioblastoma malignancy, and hyperuricemia-related diseases, providing potential therapeutic targets for these conditions.