Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Atp1b1em1flox/Cya
Common Name:
Atp1b1-flox
Product ID:
S-CKO-19043
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Atp1b1-flox
Strain ID
CKOCMP-11931-Atp1b1-B6J-VB
Gene Name
Atp1b1
Product ID
S-CKO-19043
Gene Alias
Atp4b; Atpb; Atpb-1; NKbeta1
Background
C57BL/6JCya
NCBI ID
11931
Modification
Conditional knockout
Chromosome
1
Phenotype
MGI:88108
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Atp1b1em1flox/Cya mice (Catalog S-CKO-19043) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000027863
NCBI RefSeq
NM_009721
Target Region
Exon 3~4
Size of Effective Region
~2.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
ATP1B1, encoding the Na,K-ATPase β subunit, is a key regulator of the Na+ and K+ electrochemical gradients across the plasma membrane, which is essential for regulating cellular activity. It is involved in various biological processes and is associated with multiple pathways, such as those related to cell adhesion, antiviral innate immunity, and the regulation of cell proliferation, migration, and invasion [2,4,6].

In cancer research, ATP1B1 is overexpressed in diffuse large B-cell lymphoma (DLBCL) cell lines and its expression levels can impact the prognosis of DLBCL patients. Downregulation of ATP1B1 inhibits DLBCL cell proliferation, migration, invasion, and adhesion, and roxithromycin can rescue the higher proliferation ability in ATP1B1-overexpression cells [4]. In cytogenetically normal acute myeloid leukemia (CN-AML), high ATP1B1 expression is associated with shorter overall survival and event-free survival, and it may contribute to leukemogenicity through up-regulation of oncogenes/onco-microRNAs [6]. Rapamycin inhibits the progression of human acute myeloid leukemia by regulating the circ_0094100/miR-217/ATP1B1 axis [8]. In addition, in NRG1 fusion-driven tumors, ATP1B1 is identified as a fusion partner of NRG1, and drugs targeting the related pathways may be potential therapeutic strategies [1,3].

In antiviral innate immunity, ATP1B1 can be induced by DNA and RNA virus infections, inhibit viral replication, and increase the levels of IFNs, IFN-stimulated genes, and inflammatory cytokines by potentiating the ubiquitination of TRAF3 and TRAF6 [2].

In boar sperm, the relative mRNA expression level of ATP1B1 is significantly higher in fresh sperm of the group with good semen freezability, indicating it may be a promising cryotolerance marker [5].

In alveolar epithelial cells, a study identified proteins interacting with ATP1B1, providing new insights into its role in maintaining alveolar epithelial barrier integrity [7].

In astrocytes, the interaction of DCF1 with ATP1B1 impairs astrocyte structural plasticity via the P38 signaling pathway [9].

In Fuchs endothelial corneal dystrophy, intergenic variants are associated with decreased ATP1B1 expression [10].

In conclusion, ATP1B1 is crucial for maintaining normal cellular functions, and its dysregulation is involved in multiple diseases, including various cancers, viral infections, and corneal dystrophy. Research on ATP1B1, especially through studies in disease-relevant models, helps to understand the underlying molecular mechanisms, providing potential diagnostic biomarkers and therapeutic targets for these diseases.

References:
1. Laskin, J, Liu, S V, Tolba, K, Solca, F, Duruisseaux, M. 2020. NRG1 fusion-driven tumors: biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents. In Annals of oncology : official journal of the European Society for Medical Oncology, 31, 1693-1703. doi:10.1016/j.annonc.2020.08.2335. https://pubmed.ncbi.nlm.nih.gov/32916265/
2. Cao, Wei, Guo, Yifei, Cheng, Zhikui, Liu, Shi, Zhu, Ying. 2021. Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6. In Journal of immunology (Baltimore, Md. : 1950), 206, 2668-2681. doi:10.4049/jimmunol.2001262. https://pubmed.ncbi.nlm.nih.gov/34011520/
3. Schram, Alison M, Odintsov, Igor, Espinosa-Cotton, Madelyn, Drilon, Alexander, Somwar, Romel. . Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements. In Cancer discovery, 12, 1233-1247. doi:10.1158/2159-8290.CD-21-1119. https://pubmed.ncbi.nlm.nih.gov/35135829/
4. Zhang, Shuo, Wang, Hongmin, Liu, Aichun. . Identification of ATP1B1, a key copy number driver gene in diffuse large B-cell lymphoma and potential target for drugs. In Annals of translational medicine, 10, 1136. doi:10.21037/atm-22-4709. https://pubmed.ncbi.nlm.nih.gov/36388804/
5. Mańkowska, Anna, Gilun, Przemysław, Zasiadczyk, Łukasz, Sobiech, Przemysław, Fraser, Leyland. 2022. Expression of TXNRD1, HSPA4L and ATP1B1 Genes Associated with the Freezability of Boar Sperm. In International journal of molecular sciences, 23, . doi:10.3390/ijms23169320. https://pubmed.ncbi.nlm.nih.gov/36012584/
6. Shi, Jin-long, Fu, Lin, Ang, Qing, Zhu, Jun, Wang, Wei-dong. . Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia. In Oncotarget, 7, 2585-95. doi:10.18632/oncotarget.6226. https://pubmed.ncbi.nlm.nih.gov/26506237/
7. Zheng, Yu, Peng, Weiting, Wen, Xupeng, Wan, Qiquan. 2024. Protein interactome analysis of ATP1B1 in alveolar epithelial cells using Co-Immunoprecipitation mass spectrometry and parallel reaction monitoring assay. In Heliyon, 10, e32579. doi:10.1016/j.heliyon.2024.e32579. https://pubmed.ncbi.nlm.nih.gov/38912441/
8. Cao, Jiufang, Huang, Shihua, Li, Xiaoming. 2022. Rapamycin inhibits the progression of human acute myeloid leukemia by regulating the circ_0094100/miR-217/ATP1B1 axis. In Experimental hematology, 112-113, 60-69.e2. doi:10.1016/j.exphem.2022.07.298. https://pubmed.ncbi.nlm.nih.gov/35901982/
9. Wang, Jiao, Zhou, Fangfang, Wang, Dong, Xie, Jiang, Wen, Tieqiao. 2018. Interaction of DCF1 with ATP1B1 induces impairment in astrocyte structural plasticity via the P38 signaling pathway. In Experimental neurology, 302, 214-229. doi:10.1016/j.expneurol.2018.01.007. https://pubmed.ncbi.nlm.nih.gov/29337145/
10. Chakraborty, Maynak, Jandhyam, Harithalakshmi, Basak, Samar Kumar, Das, Sujata, Alone, Debasmita Pankaj. 2023. Intergenic variants, rs1200114 and rs1200108 are genetically associated along with a decreased ATP1B1 expression in Fuchs Endothelial Corneal Dystrophy. In Experimental eye research, 228, 109403. doi:10.1016/j.exer.2023.109403. https://pubmed.ncbi.nlm.nih.gov/36736852/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest