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C57BL/6JCya-Zfp703em1flox/Cya
Common Name:
Zfp703-flox
Product ID:
S-CKO-19049
Background:
C57BL/6JCya
Product Type
Age
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Basic Information
Strain Name
Zfp703-flox
Strain ID
CKOCMP-353310-Zfp703-B6J-VB
Gene Name
Zfp703
Product ID
S-CKO-19049
Gene Alias
1110032O19Rik; Csmn1; End2; Zeppo1; Znf703; Zpo1
Background
C57BL/6JCya
NCBI ID
353310
Modification
Conditional knockout
Chromosome
8
Phenotype
MGI:2662729
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zfp703em1flox/Cya mice (Catalog S-CKO-19049) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000154256
NCBI RefSeq
NM_001101502
Target Region
Exon 2
Size of Effective Region
~2.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Zfp703, with its functions still being explored, is involved in key biological pathways. It has been shown to be related to the Wnt/β -catenin signaling pathway, which controls embryonic development and adult stem cell maintenance. Malregulation of this pathway can lead to embryonic malformations and cancer, highlighting Zfp703's potential importance in these processes [1].

One study demonstrated that Zfp703 is a Wnt target gene. It inhibits Wnt/β -catenin activity in Wnt reporter assays and Wnt -dependent mesoderm differentiation in embryonic stem cells. Zfp703 binds directly to Tcf1 to prevent β -catenin/Tcf1 complex formation, functioning independently of the Groucho/Tle transcriptional corepressor [1]. Another study found that Zfp703 is among the genes whose expression is affected during retinoic acid -induced differentiation of neuromesodermal progenitors, suggesting its role in body axis extension [2]. Additionally, in the context of prostate gland adaptation to the hypoandrogenic environment, Zfp703 was identified as one of the transiently expressed transcription -regulating genes, with its mRNA present in both epithelial and stromal cells [3].

In conclusion, Zfp703 plays diverse roles in embryonic development-related processes such as mesoderm differentiation and body axis extension, as well as in the prostate gland's response to androgen deprivation. These findings from various studies enhance our understanding of Zfp703's biological functions and its potential implications in related diseases. Although no KO/CKO mouse model findings were explicitly presented in the provided references, the identified functions give a basis for further in-vivo functional studies.

References:
1. Kumar, Amit, Chalamalasetty, Ravindra B, Kennedy, Mark W, Garriock, Robert J, Yamaguchi, Terry P. 2016. Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex. In Molecular and cellular biology, 36, 1793-802. doi:10.1128/MCB.01010-15. https://pubmed.ncbi.nlm.nih.gov/27090637/
2. Cunningham, Thomas J, Colas, Alexandre, Duester, Gregg. 2016. Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors. In Biology open, 5, 1821-1833. doi:10.1242/bio.020891. https://pubmed.ncbi.nlm.nih.gov/27793834/
3. Nishan, Umar, Rosa-Ribeiro, Rafaela, Cesar, Carlos Lenz, Carvalho, Hernandes F. 2019. Transcription regulators are transiently expressed during the prostate gland adaptation to the hypoandrogenic environment. In Histology and histopathology, 34, 1025-1036. doi:10.14670/HH-18-105. https://pubmed.ncbi.nlm.nih.gov/30912572/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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