C57BL/6JCya-Ifi207em1flox/Cya
Common Name:
Ifi207-flox
Product ID:
S-CKO-19065
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Ifi207-flox
Strain ID
CKOCMP-226691-Ifi207-B6J-VA
Gene Name
Product ID
S-CKO-19065
Gene Alias
Pyhin-A; pyhinA
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
1
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ifi207em1flox/Cya mice (Catalog S-CKO-19065) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000042610
NCBI RefSeq
NM_001204910
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Ifi207 is a member of the PYHIN and Alr gene families. It is a young and fast-evolving gene that plays crucial roles in innate immunity, particularly in cytokine regulation and antiviral responses. It is involved in pathways such as the STING-mediated response, which is important for the body's defense against pathogens [2,3].
Generation of Ifi207-/-mice showed that IFI207 is not involved in autoimmunity. Instead, it is required for the establishment of Klebsiella pneumoniae lung infection and macrophage phagocytosis of Klebsiella [1]. In addition, in vivo studies demonstrated that IFI207 controls murine leukemia virus (MLV) infection by stabilizing STING protein through its distinctive repeat region in the STING-mediated response to cGAMP, DNA, and MLV [2,3].
In conclusion, Ifi207 is essential for innate immune responses, contributing to the regulation of cytokine transcription, pathogen-specific infections like K. pneumoniae, and antiviral defense against retroviruses such as MLV. The use of Ifi207 knockout mouse models has been instrumental in revealing its functions in these biological processes and disease-related contexts.
References：
1. Baran, Marcin, Feriotti, Claudia, McGinley, Aoife, Bengeochea, Jose A, Bowie, Andrew G. 2023. PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection. In Cell reports, 42, 112341. doi:10.1016/j.celrep.2023.112341. https://pubmed.ncbi.nlm.nih.gov/37018072/
2. Moran, Eileen A, Salas-Briceno, Karen, Aguilera, Alexya N, Lilue, Jingtao, Ross, Susan R. 2023. IFI207, a young and fast-evolving antiviral factor, stabilizes STING. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.01.19.524411. https://pubmed.ncbi.nlm.nih.gov/36711784/
3. Moran, Eileen A, Salas-Briceno, Karen, Zhao, Wenming, Lilue, Jingtao, Ross, Susan R. 2024. IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway. In mBio, 15, e0120924. doi:10.1128/mbio.01209-24. https://pubmed.ncbi.nlm.nih.gov/38860764/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen