C57BL/6JCya-Sgczem1flox/Cya
Common Name:
Sgcz-flox
Product ID:
S-CKO-19086
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Sgcz-flox
Strain ID
CKOCMP-244431-Sgcz-B6J-VB
Gene Name
Product ID
S-CKO-19086
Gene Alias
C230085N17Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sgczem1flox/Cya mice (Catalog S-CKO-19086) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000118896
NCBI RefSeq
NM_145841
Target Region
Exon 4
Size of Effective Region
~0.8 kb
Detailed Document
Overview of Gene Research
SGCZ, also known as zeta-sarcoglycan gene, is expressed in brain tissue among other tissues. E-and ζ-sarcoglycan are expressed in the brain, and SGCZ may be involved in processes related to certain disorders [1]. However, no pathogenic SGCZ mutations were found to contribute to the genetic heterogeneity in myoclonus dystonia syndrome (MDS), suggesting it is unlikely to be associated with this disorder [1].
SGCZ has also been associated with other conditions. A genome-wide association study found SGCZ to be associated with prediabetes status change, indicating its potential role in diabetes-related processes [2]. In a study on a unique broiler population, the expression level of SGCZ in abdominal fat tissue differed significantly between fat and lean broilers, showing its possible connection with fatness traits [3]. In breast cancer, SGCZ ranked top for the recurrent copy number alteration (CNA) loss regions, and its expression level was significantly associated with survival outcome in young women with breast cancer [4].
In summary, SGCZ appears to be involved in a variety of biological processes and disease conditions, including those related to movement disorders, diabetes, fat deposition, and breast cancer. Studies on SGCZ contribute to understanding the genetic basis of these conditions, potentially providing new insights for diagnosis, treatment, and prevention.
References:
1. Peall, K J, Ritz, K, Waite, A J, Blake, D J, Tijssen, M A J. 2014. SGCZ mutations are unlikely to be associated with myoclonus dystonia. In Neuroscience, 272, 88-91. doi:10.1016/j.neuroscience.2014.04.034. https://pubmed.ncbi.nlm.nih.gov/24792710/
2. Liu, Tingting, Li, Hongjin, Conley, Yvette P, Lo, Wen-Juo, Li, Changwei. 2022. A Genome-Wide Association Study of Prediabetes Status Change. In Frontiers in endocrinology, 13, 881633. doi:10.3389/fendo.2022.881633. https://pubmed.ncbi.nlm.nih.gov/35769078/
3. Jin, Pengcheng, Wu, Xianwen, Xu, Songsong, Li, Hui, Wang, Shouzhi. 2015. Differential expression of six genes and correlation with fatness traits in a unique broiler population. In Saudi journal of biological sciences, 24, 945-949. doi:10.1016/j.sjbs.2015.04.014. https://pubmed.ncbi.nlm.nih.gov/28490969/
4. Chi, Chen, Murphy, Leigh C, Hu, Pingzhao. 2018. Recurrent copy number alterations in young women with breast cancer. In Oncotarget, 9, 11541-11558. doi:10.18632/oncotarget.24336. https://pubmed.ncbi.nlm.nih.gov/29545918/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen