C57BL/6JCya-Anapc13em1flox/Cya
Common Name:
Anapc13-flox
Product ID:
S-CKO-19089
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Anapc13-flox
Strain ID
CKOCMP-69010-Anapc13-B6J-VB
Gene Name
Product ID
S-CKO-19089
Gene Alias
1810004D07Rik; APC13; SWM1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Anapc13em1flox/Cya mice (Catalog S-CKO-19089) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000190279
NCBI RefSeq
NM_181394
Target Region
Exon 2~3
Size of Effective Region
~5.3 kb
Detailed Document
Overview of Gene Research
Anapc13, whose specific function details are yet to be fully elaborated, has been implicated in various biological processes. It has been associated with pathways related to cell proliferation regulation, as well as in some disease-related contexts such as cancer, chronic pancreatitis, and atopic asthma [1,2,4,5]. Animal models like gene-modified mice can be valuable in further exploring its function.
In a study on Treg-specific expression of SF3B1-K700E in mice, SF3B1-K700E induced an aberrant splicing event in Anapc13, reducing its expression. Forced expression of Anapc13 restored the differentiation and function of Tregs in preventing adoptive-transfer colitis, highlighting Anapc13's role in regulating Treg function, which in turn impacts immune responses and cancer development [1]. In breast ductal carcinoma, down-regulation of Anapc13 was an early event in the progression of pre-invasive ductal carcinoma, and its down-regulation was associated with genomic instability in this disease [3].
In conclusion, Anapc13 appears to play a significant role in processes related to immune regulation and cancer progression. The findings from mouse models, especially those related to Treg function and breast cancer progression, contribute to our understanding of the biological functions of Anapc13 and its implications in specific disease areas.
References:
1. Shi, Yun, Zhang, Wencan, Jia, Qiong, Kuo, Ya-Huei, Sun, Zuoming. 2024. Cancer-associated SF3B1-K700E mutation controls immune responses by regulating Treg function via aberrant Anapc13 splicing. In Science advances, 10, eado4274. doi:10.1126/sciadv.ado4274. https://pubmed.ncbi.nlm.nih.gov/39303038/
2. Wang, Dan, Xin, Lei, Lin, Jin-Huan, Li, Zhao-Shen, Hu, Liang-Hao. . Identifying miRNA-mRNA regulation network of chronic pancreatitis based on the significant functional expression. In Medicine, 96, e6668. doi:10.1097/MD.0000000000006668. https://pubmed.ncbi.nlm.nih.gov/28538367/
3. Sens-Abuázar, Carolina, Napolitano E Ferreira, Elisa, Osório, Cynthia Aparecida Bueno Toledo, Rocha, Rafael Malagoli, Carraro, Dirce Maria. 2012. Down-regulation of ANAPC13 and CLTCL1: Early Events in the Progression of Preinvasive Ductal Carcinoma of the Breast. In Translational oncology, 5, 113-23. doi:. https://pubmed.ncbi.nlm.nih.gov/22496928/
4. Yan, Qi, Forno, Erick, Cardenas, Andres, Koppelman, Gerard H, Celedón, Juan C. 2021. Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children. In Pediatric pulmonology, 56, 1896-1905. doi:10.1002/ppul.25372. https://pubmed.ncbi.nlm.nih.gov/33751861/
5. Yan, Qi, Forno, Erick, Cardenas, Andres, Koppelman, Gerard H, Celedón, Juan C. 2020. Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children. In medRxiv : the preprint server for health sciences, , . doi:10.1101/2020.11.03.20225250. https://pubmed.ncbi.nlm.nih.gov/33173928/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen