C57BL/6JCya-Sdc3em1flox/Cya
Common Name
Sdc3-flox
Product ID
S-CKO-19095
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-20970-Sdc3-B6J-VB
When using this mouse strain in a publication, please cite “Sdc3-flox Mouse (Catalog S-CKO-19095) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Sdc3-flox
Strain ID
CKOCMP-20970-Sdc3-B6J-VB
Gene Name
Product ID
S-CKO-19095
Gene Alias
Synd3, mKIAA0468, syn-3
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000070478
NCBI RefSeq
NM_011520
Target Region
Exon 3~4
Size of Effective Region
~3.6 kb
Overview of Gene Research
Syndecan-3 (SDC3) is a member of the syndecan family of cell-surface molecules. It has diverse biological roles, participating in processes like angiogenesis, inflammation, and neural-related functions [2]. In the context of muscle stem cells, it modulates the INSR/AKT/mTOR pathway, acting as a regulator of myogenesis to prevent premature differentiation [7].
In Alzheimer's disease (AD), SDC3 was found to be differentially expressed in cholinergic SN56 cells carrying the Swedish APP (APPSWE) mutation. Knockdown of SDC3 attenuated oxidative stress-induced cell death in these cells, suggesting it mediates the specific effects of APPSWE on cholinergic neurodegeneration in AD [1]. In apparent treatment-resistant hypertension (aTRH), a genome-wide association study identified a novel association between SDC3 and aTRH, with lower expression of SDC3 in aTRH patients [3]. In ovarian cancer, lncRNA TRPM2-AS promotes cancer progression and cisplatin resistance by sponging miR-138-5p to release SDC3 mRNA [4]. In renal cell carcinoma, circRNA SCARB1 promotes cancer progression via the miR-510-5p/SDC3 axis [5]. In melanoma, LINC01116 facilitates progression by sequestering miR-3612 and up-regulating SDC3 [6].
In summary, SDC3 is involved in multiple biological processes and disease conditions. Studies, including those using gene-knockdown models, have revealed its role in neurodegeneration, hypertension, and several types of cancers. Understanding SDC3's functions in these contexts may provide potential therapeutic targets for the related diseases.
References：
1. Wang, Juelu, Chen, Peiye, Hu, Bolang, Wu, Yili, Song, Weihong. . Distinct effects of SDC3 and FGFRL1 on selective neurodegeneration in AD and PD. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37, e22773. doi:10.1096/fj.202201359R. https://pubmed.ncbi.nlm.nih.gov/36629784/
2. Arokiasamy, Samantha, Balderstone, Michaela J M, De Rossi, Giulia, Whiteford, James R. 2020. Syndecan-3 in Inflammation and Angiogenesis. In Frontiers in immunology, 10, 3031. doi:10.3389/fimmu.2019.03031. https://pubmed.ncbi.nlm.nih.gov/31998313/
3. Xiao, Xiao, Li, Rui, Wu, Cunjin, Hui, Rutai, Wang, Yibo. 2022. A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension. In BMC medicine, 20, 463. doi:10.1186/s12916-022-02665-x. https://pubmed.ncbi.nlm.nih.gov/36447229/
4. Ding, Yi, Tan, Xiangyu, Abasi, Abuduyilimu, Yan, Miao, Huang, Xiaoyuan. 2021. LncRNA TRPM2-AS promotes ovarian cancer progression and cisplatin resistance by sponging miR-138-5p to release SDC3 mRNA. In Aging, 13, 6832-6848. doi:10.18632/aging.202541. https://pubmed.ncbi.nlm.nih.gov/33621194/
5. Sun, Jijian, Pan, Shijie, Cui, Hongquan, Li, Hao. . CircRNA SCARB1 Promotes Renal Cell Carcinoma Progression Via Mir- 510-5p/SDC3 Axis. In Current cancer drug targets, 20, 461-470. doi:10.2174/1568009620666200409130032. https://pubmed.ncbi.nlm.nih.gov/32271695/
6. Wang, Kai, Li, Min, Zhang, Tong, Yu, Feifei, Duan, Hongyan. 2021. LINC01116 Facilitates Melanoma 1 Progression Via Sequestering miR-3612 and Up-regulating GDF11 and SDC3. In Archives of medical research, 53, 44-50. doi:10.1016/j.arcmed.2021.06.008. https://pubmed.ncbi.nlm.nih.gov/34266696/
7. Jones, Fiona K, Phillips, Alexander M, Jones, Andrew R, Pisconti, Addolorata. 2022. The INSR/AKT/mTOR pathway regulates the pace of myogenesis in a syndecan-3-dependent manner. In Matrix biology : journal of the International Society for Matrix Biology, 113, 61-82. doi:10.1016/j.matbio.2022.09.004. https://pubmed.ncbi.nlm.nih.gov/36152781/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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