Wfdc18, also known as WDNM1 or Expi, is a gene encoding a protein that belongs to the 'four-disulphide core' family of proteins, potentially with proteinase inhibiting capacity [4]. It may be involved in various biological processes, as its expression changes are associated with different physiological and pathological conditions.

In sika deer antler development, Wfdc18 was found to be abundant at the ossification stage, indicating its potential role in the transition from the growth to the ossification of antlers [1]. In an imiquimod-induced psoriasis model, sakuranetin treatment upregulated Wfdc18, suggesting its possible involvement in epidermal homeostasis and skin barrier function modulation [2]. In mouse studies related to liver fibrosis, Wfdc18 within a 6 Mb interval on chromosome 11 was ranked as a strong candidate gene that may modulate the severity of liver fibrosis [3].

In conclusion, Wfdc18 is implicated in multiple biological processes such as antler ossification, skin barrier function, and liver fibrosis. The findings from these studies using different research models, including in vivo models, contribute to understanding the gene's functions in specific biological processes and disease-related conditions, highlighting its potential importance in these areas.