C57BL/6JCya-Aipem1flox/Cya
Common Name:
Aip-flox
Product ID:
S-CKO-19122
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Aip-flox
Strain ID
CKOCMP-11632-Aip-B6J-VB
Gene Name
Product ID
S-CKO-19122
Gene Alias
Ara9; D19Bwg1412e; Fkbp16; Xap2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Aipem1flox/Cya mice (Catalog S-CKO-19122) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000117831
NCBI RefSeq
NM_016666
Target Region
Exon 3~7
Size of Effective Region
~4.5 kb
Detailed Document
Overview of Gene Research
Aip, short for aryl hydrocarbon receptor-interacting protein, is a co-chaperone of heat-shock protein 90 and various nuclear receptors. It belongs to the family of tetratricopeptide repeat (TPR)-containing proteins and has three TPR domains mediating its interactions with partners. Germline mutations in Aip predispose to young-onset pituitary tumours, often GH-or prolactin-secreting adenomas, suggesting its importance in pituitary gland function [2].
Germline loss-of-function heterozygote mutations in Aip lead to a predisposition to growth hormone-or prolactin-secreting pituitary tumours, typically presenting in childhood, indicating its role as a tumour suppressor in the context of pituitary tumourigenesis [3]. AIP mutations are rare in sporadic acromegaly but are more frequent among certain pituitary adenoma patient populations, such as those with pituitary gigantism (29% of this group have AIP gene mutations), familial isolated pituitary adenoma (FIPA) kindreds, and patients with macroadenomas diagnosed ≤30 years old [1].
In conclusion, Aip functions as a co-chaperone and is crucial in pituitary gland-related biological processes. The study of Aip, especially through understanding the effects of its loss-of-function mutations, has significant implications for the diagnosis and treatment of pituitary-related diseases like pituitary gigantism, acromegaly, and familial isolated pituitary adenomas.
References:
1. Rostomyan, Liliya, Potorac, Iulia, Beckers, Pablo, Daly, Adrian F, Beckers, Albert. 2017. AIP mutations and gigantism. In Annales d'endocrinologie, 78, 123-130. doi:10.1016/j.ando.2017.04.012. https://pubmed.ncbi.nlm.nih.gov/28483363/
2. Trivellin, Giampaolo, Korbonits, Márta. 2011. AIP and its interacting partners. In The Journal of endocrinology, 210, 137-55. doi:10.1530/JOE-11-0054. https://pubmed.ncbi.nlm.nih.gov/21454441/
3. Haworth, Oliver, Korbonits, Márta. 2022. AIP: A double agent? The tissue-specific role of AIP as a tumour suppressor or as an oncogene. In British journal of cancer, 127, 1175-1176. doi:10.1038/s41416-022-01964-7. https://pubmed.ncbi.nlm.nih.gov/36064587/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen