C57BL/6JCya-Sorbs2em1flox/Cya
Common Name:
Sorbs2-flox
Product ID:
S-CKO-19169
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Sorbs2-flox
Strain ID
CKOCMP-234214-Sorbs2-B6J-VB
Gene Name
Product ID
S-CKO-19169
Gene Alias
2010203O03Rik; 9430041O17Rik; A530071H08; Argbp2; mKIAA0777; nArgBP2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sorbs2em1flox/Cya mice (Catalog S-CKO-19169) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000171337
NCBI RefSeq
NM_001205219
Target Region
Exon 8
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
Sorbs2, also known as Sorbin and SH3 Domain Containing 2, is ubiquitously expressed in various tissues including the cardiovascular system. It serves as a cytoskeletal adaptor and an RNA-binding protein, regulating important biological processes. It is involved in pathways related to ion channel regulation, cell-matrix interactions, and inflammation, which are crucial for normal physiological functions [1,2]. Genetic models like knockout mice are valuable for studying its functions.
In gene knockout studies, Sorbs2-knockout mice at 4 months old showed decreased BK channel expression and function in coronary arteries, along with impaired Ca2 +-sensitivity and vasodilation, mimicking diabetic vascular phenotypes [2]. Cardiomyocyte-specific Sorbs2 knockout (Sorbs2-cKO) mice developed progressive systolic dysfunction, enlarged cardiac chambers, and died of congestive heart failure around 1 year old. Early intracellular structural remodeling due to defective microtubule polymerization was found to be responsible for contractile dysfunction [3].
In conclusion, Sorbs2 is essential for maintaining the structural integrity of cardiomyocytes and regulating ion channel functions in blood vessels. The Sorbs2 KO/CKO mouse models have significantly contributed to understanding its role in cardiovascular diseases, providing insights into potential disease mechanisms and possible therapeutic targets in this area.
References:
1. Xiong, Xiaowei, Lee, Hon-Chi, Lu, Tong. 2025. Impact of Sorbs2 dysfunction on cardiovascular diseases. In Biochimica et biophysica acta. Molecular basis of disease, 1871, 167813. doi:10.1016/j.bbadis.2025.167813. https://pubmed.ncbi.nlm.nih.gov/40139410/
2. Sun, Xiaojing, Lee, Hon-Chi, Lu, Tong. 2024. Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes. In Circulation research, 134, 858-871. doi:10.1161/CIRCRESAHA.123.323538. https://pubmed.ncbi.nlm.nih.gov/38362769/
3. McLendon, Jared M, Zhang, Xiaoming, Matasic, Daniel S, London, Barry, Boudreau, Ryan L. 2022. Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice. In Journal of the American Heart Association, 11, e025687. doi:10.1161/JAHA.122.025687. https://pubmed.ncbi.nlm.nih.gov/35730644/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen