C57BL/6JCya-Haghem1flox/Cya
Common Name:
Hagh-flox
Product ID:
S-CKO-19206
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Hagh-flox
Strain ID
CKOCMP-14651-Hagh-B6J-VB
Gene Name
Product ID
S-CKO-19206
Gene Alias
Glo-2; Glo2; Rsp29
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
17
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Haghem1flox/Cya mice (Catalog S-CKO-19206) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000118788
NCBI RefSeq
NM_024284
Target Region
Exon 3~5
Size of Effective Region
~4.6 kb
Detailed Document
Overview of Gene Research
HAGH, the hydroxyacylglutathione hydrolase gene, encodes glyoxalase 2 (Glo2), a protein belonging to the metallo-β-lactamase family [1]. Glo2 is the second enzyme of the glyoxalase system, responsible for the detoxification of the α-ketothaldehyde methylglyoxal in cells. The glyoxalase system, with Glo1 and Glo2, utilizes glutathione as a cofactor in eukaryotic cells, and is involved in processes related to oxidative stress [1].
A study on schizophrenia patients and healthy controls in a Japanese sample investigated common genetic variants in HAGH. The SNP rs11859266 in the intronic region of HAGH showed a nominally significant association with schizophrenia (p = 0.020), though it did not survive multiple testing (empirical p = 0.091). In males, rs11859266 and rs3743852 in HAGH showed significant associations with schizophrenia at allelic and genotype levels, with some persistence after multiple testing [2].
In conclusion, HAGH is crucial for the function of the glyoxalase system in detoxifying methylglyoxal. Genetic studies of HAGH, such as those in schizophrenia, help to understand its role in disease-related processes. These findings contribute to uncovering the relationship between the glyoxalase system and certain diseases, providing insights into potential disease mechanisms and possible therapeutic targets.
References:
1. Scirè, Andrea, Cianfruglia, Laura, Minnelli, Cristina, Antognelli, Cinzia, Armeni, Tatiana. 2022. Glyoxalase 2: Towards a Broader View of the Second Player of the Glyoxalase System. In Antioxidants (Basel, Switzerland), 11, . doi:10.3390/antiox11112131. https://pubmed.ncbi.nlm.nih.gov/36358501/
2. Bangel, Fabian N, Yamada, Kazuo, Arai, Makoto, Stork, Oliver, Yoshikawa, Takeo. 2015. Genetic analysis of the glyoxalase system in schizophrenia. In Progress in neuro-psychopharmacology & biological psychiatry, 59, 105-110. doi:10.1016/j.pnpbp.2015.01.014. https://pubmed.ncbi.nlm.nih.gov/25645869/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen