C57BL/6JCya-Try10em1flox/Cya
Common Name:
Try10-flox
Product ID:
S-CKO-19277
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Try10-flox
Strain ID
CKOCMP-436522-Try10-B6J-VA
Gene Name
Product ID
S-CKO-19277
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Try10em1flox/Cya mice (Catalog S-CKO-19277) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000072103
NCBI RefSeq
NM_001038996
Target Region
Exon 2~5
Size of Effective Region
~4.1 kb
Detailed Document
Overview of Gene Research
Check the content of the review
Try10, from the provided references, seems to be involved in retinal ganglion cell (RGC) related processes. In a study exploring RGC loss, Try10 was among eight proteins that were differentially expressed for at least two time points in the temporal retina compared to the nasal retina after unilateral partial optic nerve transection in rats [1].
The differential expression of Try10 in the context of RGC damage implies its potential role in the response to such injury. However, the references do not provide information from gene knockout (KO) or conditional knockout (CKO) mouse models.
In conclusion, Try10's differential expression in the retina during RGC loss suggests it may have an important function in retinal neuron and glia responses to injury. Further research using KO or CKO mouse models could potentially reveal more about its role in retinal diseases related to RGC damage.
References：
1. Kwong, Jacky M K, Caprioli, Joseph, Lee, Joanne C Y, To, Chi-Ho, Lam, Thomas Chuen. 2023. Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration. In International journal of molecular sciences, 24, . doi:10.3390/ijms241512109. https://pubmed.ncbi.nlm.nih.gov/37569482/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen