C57BL/6JCya-Tmem87bem1flox/Cya
Common Name:
Tmem87b-flox
Product ID:
S-CKO-19336
Background:
C57BL/6JCya
Product Type
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Basic Information
Strain Name
Tmem87b-flox
Strain ID
CKOCMP-72477-Tmem87b-B6J-VB
Gene Name
Product ID
S-CKO-19336
Gene Alias
2610301K12Rik; 2810431I02Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tmem87bem1flox/Cya mice (Catalog S-CKO-19336) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000110325
NCBI RefSeq
NM_028248
Target Region
Exon 6~8
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
TMEM87B is a eukaryotic transmembrane protein. Along with TMEM87A, they are members of a protein family with proposed roles in protein transport to and from the Golgi, as mechanosensitive ion channels, and in developmental signaling [2]. Disruptions in TMEM87s have been linked to cancers and developmental disorders [2].
In glioma, TMEM87B was identified as a downstream gene of KLF11. KLF11 positively regulates its expression, and high TMEM87B expression in glioma samples indicates a poor prognosis. Eliminating TMEM87B reduces glioma cell proliferation, migration, and tumor spheroid formation, while increasing sensitivity to the drug TMZ [1].
In a patient with a 2q13 microdeletion, a TMEM87B mutation was found, suggesting its role in an autosomal-recessive disorder characterized by severe cardiac phenotypes. Zebrafish studies also show that TMEM87B depletion affects cardiac development, leading to cardiac hypoplasia [3].
In conclusion, TMEM87B plays important roles in glioma progression and sensitivity to treatment, as well as in cardiac development. Its disruption is associated with congenital heart diseases and may contribute to the etiology of 2q13 deletion-related disorders. Research on TMEM87B using models like zebrafish and in glioma cell lines helps understand its functions and potential as a therapeutic target in these disease areas.
References：
1. Li, Jian, Zong, Hua, Zhao, Xiaoli, Li, Ning, Li, Zhuolun. 2025. KLF11/TMEM87B promoted the occurrence of glioma and decreased TMZ sensitivity. In Cellular signalling, 130, 111651. doi:10.1016/j.cellsig.2025.111651. https://pubmed.ncbi.nlm.nih.gov/39929351/
2. Hoel, Christopher M, Zhang, Lin, Brohawn, Stephen G. 2022. Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A. In eLife, 11, . doi:10.7554/eLife.81704. https://pubmed.ncbi.nlm.nih.gov/36373655/
3. Yu, Hung-Chun, Coughlin, Curtis R, Geiger, Elizabeth A, Miyamoto, Shelley D, Shaikh, Tamim H. . Discovery of a potentially deleterious variant in TMEM87B in a patient with a hemizygous 2q13 microdeletion suggests a recessive condition characterized by congenital heart disease and restrictive cardiomyopathy. In Cold Spring Harbor molecular case studies, 2, a000844. doi:10.1101/mcs.a000844. https://pubmed.ncbi.nlm.nih.gov/27148590/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen