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C57BL/6JCya-Msrb3em1flox/Cya
Common Name:
Msrb3-flox
Product ID:
S-CKO-19352
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Msrb3-flox
Strain ID
CKOCMP-320183-Msrb3-B6J-VB
Gene Name
Msrb3
Product ID
S-CKO-19352
Gene Alias
D430026P16Rik; I-8-23; MsrB2
Background
C57BL/6JCya
NCBI ID
320183
Modification
Conditional knockout
Chromosome
10
Phenotype
MGI:2443538
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Msrb3em1flox/Cya mice (Catalog S-CKO-19352) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000092143
NCBI RefSeq
NM_177092
Target Region
Exon 6
Size of Effective Region
~1.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
MsrB3, short for methionine sulfoxide reductase B3, is a protein repair enzyme. It specifically catalyzes the reduction of methionine-R-sulfoxide residues and has an antioxidant function [2,4]. It is involved in multiple biological processes, with its location in the endoplasmic reticulum (ER) suggesting a role in ER-related redox regulation [3,5].

MsrB3 deficiency in cancer cells has been studied. It induces apoptosis through p53-independent and ER stress-dependent pathways. MsrB3 depletion leads to post-transcriptional down-regulation of p53, and apoptosis occurs to a similar extent in p53 wild-type and null cancer cells. It also significantly increases ER stress, activates the pro-apoptotic Bim molecule, and disturbs calcium homeostasis in the ER [1]. In clear cell renal cell carcinoma, knockdown of MSRB3 arrests cell proliferation, migration, and invasion, while promoting apoptosis and inducing ER stress marker changes [2]. In zebrafish, down-regulation of msrb3 causes hair cell apoptosis, leading to abnormal auditory system development [6]. In cattle, polymorphisms in the MSRB3 gene are associated with growth traits [7].

In conclusion, MsrB3 plays a crucial role in multiple biological processes and disease conditions. Its deficiency-induced apoptosis in cancer cells, its impact on the development of the auditory system in zebrafish, and its association with growth traits in cattle, as revealed through functional studies, provide important insights. Understanding MsrB3 helps in grasping the underlying mechanisms of these biological processes and diseases, potentially offering new strategies for treatment and breeding improvement.

References:
1. Kwak, Geun-Hee, Kim, Hwa-Young. 2017. MsrB3 deficiency induces cancer cell apoptosis through p53-independent and ER stress-dependent pathways. In Archives of biochemistry and biophysics, 621, 1-5. doi:10.1016/j.abb.2017.04.001. https://pubmed.ncbi.nlm.nih.gov/28389299/
2. Ye, Xuxiao, Liang, Tao, Deng, Chao, Li, Zuowei, Yan, Dongliang. 2019. MSRB3 promotes the progression of clear cell renal cell carcinoma via regulating endoplasmic reticulum stress. In Pathology, research and practice, 216, 152780. doi:10.1016/j.prp.2019.152780. https://pubmed.ncbi.nlm.nih.gov/31889586/
3. Javitt, Gabriel, Cao, Zhenbo, Resnick, Efrat, Bulleid, Neil J, Fass, Deborah. 2020. Structure and Electron-Transfer Pathway of the Human Methionine Sulfoxide Reductase MsrB3. In Antioxidants & redox signaling, 33, 665-678. doi:10.1089/ars.2020.8037. https://pubmed.ncbi.nlm.nih.gov/32517586/
4. Kwak, Geun-Hee, Kim, Tae-Hyoung, Kim, Hwa-Young. 2016. Down-regulation of MsrB3 induces cancer cell apoptosis through reactive oxygen species production and intrinsic mitochondrial pathway activation. In Biochemical and biophysical research communications, 483, 468-474. doi:10.1016/j.bbrc.2016.12.120. https://pubmed.ncbi.nlm.nih.gov/28007593/
5. Kwon, Sun Jae, Kwon, Soon Il, Bae, Min Seok, Cho, Eun Ju, Park, Ohkmae K. 2007. Role of the methionine sulfoxide reductase MsrB3 in cold acclimation in Arabidopsis. In Plant & cell physiology, 48, 1713-23. doi:. https://pubmed.ncbi.nlm.nih.gov/17956860/
6. Shen, Xiaofang, Liu, Fei, Wang, Yingzhi, Wang, Xu, Ma, Duan. . Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish. In The International journal of developmental biology, 59, 195-203. doi:10.1387/ijdb.140200md. https://pubmed.ncbi.nlm.nih.gov/26505252/
7. Wu, Mingli, Li, Shipeng, Zhang, Guoliang, Ma, Yun, Dang, Ruihua. 2019. Exploring insertions and deletions (indels) of MSRB3 gene and their association with growth traits in four Chinese indigenous cattle breeds. In Archives animal breeding, 62, 465-475. doi:10.5194/aab-62-465-2019. https://pubmed.ncbi.nlm.nih.gov/31807658/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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