C57BL/6JCya-Taldo1em1flox/Cya
Common Name
Taldo1-flox
Product ID
S-CKO-19419
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-21351-Taldo1-B6J-VB
When using this mouse strain in a publication, please cite “Taldo1-flox Mouse (Catalog S-CKO-19419) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Taldo1-flox
Strain ID
CKOCMP-21351-Taldo1-B6J-VB
Gene Name
Product ID
S-CKO-19419
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000026576
NCBI RefSeq
NM_011528
Target Region
Exon 2~4
Size of Effective Region
~5.7 kb
Overview of Gene Research
TALDO1, also known as transaldolase 1, is a rate-limiting enzyme in the pentose phosphate pathway. This pathway is crucial for the production of ribose-5-phosphate for nucleotide synthesis and NADPH for redox reactions, thus playing an important role in cell metabolism, growth, and maintenance [4].
TALDO1 has been associated with multiple diseases. In breast cancer, it was found to be an extracellular vesicle (EV) biomarker of distant metastasis, and in vitro and in vivo analysis confirmed its role in stimulating breast cancer invasion and metastasis [1]. In hepatocellular carcinoma (HCC), TALDO1 mRNA level was higher in cancer tissues compared to normal tissues. High TALDO1 mRNA expression was an independent risk factor for prognosis, and high expression was associated with poor overall survival. Knockdown of TALDO1 expression suppressed the proliferation and migration ability of HCC cells, and it was shown to activate the mitogen-activated protein kinase (MAPK) pathway and enhance epithelial-mesenchymal transition (EMT) [2]. Also, in estrogen receptor-positive breast cancer, TALDO1 co-expressed with SLC1A5 was associated with endocrine therapy failure [3].
In conclusion, TALDO1 is a key enzyme in the pentose phosphate pathway with important implications in metabolism. Through gene-based research, especially in cancer models such as breast cancer and HCC, it has been revealed that TALDO1 plays significant roles in tumor progression, metastasis, and response to therapy, highlighting its potential as a biomarker and therapeutic target in these disease areas.
References：
1. Xu, Ganfei, Huang, Rui, Wumaier, Reziya, Ding, Chen, Wang, Hongxia. . Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer. In Cancer research, 84, 3267-3285. doi:10.1158/0008-5472.CAN-23-3998. https://pubmed.ncbi.nlm.nih.gov/38900939/
2. Cen, Kedan, Lu, Caide. 2023. Prognostic and Immune Infiltration Analysis of Transaldolase 1 (TALDO1) in Hepatocellular Carcinoma. In International journal of general medicine, 16, 5779-5788. doi:10.2147/IJGM.S425490. https://pubmed.ncbi.nlm.nih.gov/38089714/
3. Alfarsi, Lutfi H, El Ansari, Rokaya, Craze, Madeleine L, Rakha, Emad A, Green, Andrew R. 2021. SLC1A5 co-expression with TALDO1 associates with endocrine therapy failure in estrogen receptor-positive breast cancer. In Breast cancer research and treatment, 189, 317-331. doi:10.1007/s10549-021-06298-1. https://pubmed.ncbi.nlm.nih.gov/34282517/
4. Moriyama, Tetsuji, Tanaka, Shu, Nakayama, Yasumune, Fukusaki, Eiichiro, Oka, Masahiro. 2016. Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network. In Scientific reports, 6, 34648. doi:10.1038/srep34648. https://pubmed.ncbi.nlm.nih.gov/27703206/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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